Metal Ion-Assisted Weak Interactions Involving Biological Molecules. From Small Complexes to Metalloproteins
Metal Ion-Assisted Weak Interactions Involving Biological Molecules. From Small Complexes to Metalloproteins
复制标题
涉及生物分子的金属离子辅助弱相互作用。
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
S. Hirota
中科院分区：
文献类型：
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作者：
O. Yamauchi;A. Odani;S. Hirota
非共价或弱相互作用在化学和生物体系中的分子识别和结构组织中起着重要作用。氢键和芳环堆积被广泛认为是生物分子，这些和其他类型的弱相互作用最近吸引了很多关注，作为理解生物反应效率和特异性的线索。我们研究了弱相互作用周围的金属中心的混合配体（三元）金属配合物的形成，分子识别，并通过电位，光谱和晶体学方法的自组织结构的建设的因素。研究了含酸性氨基酸和碱性氨基酸的Cu（II）和Pd（II）配合物中的配体间的静电相互作用，以及芳香氨基酸的芳香环与配位芳香配体（如2，2 ′-联吡啶）之间的芳香环堆积相互作用。Pt（II）配合物与未配位的单核苷酸类化合物之间的选择性加合物的形成。
Noncovalent or weak interactions play important roles in molecular recognition and structual organization in chemical and biological systems. Hydrogen bonding and aromatic ring stacking are widely recognized for biomolecules, and these and other types of weak interactions are recently attracting much attention as a clue to understanding the efficiency and specificity of biological reactions. We studied weak interactions around the metal center as factors for mixed ligand (ternary) metal complex formation, molecular recognition, and construction of self-organized structures by potentiometric, spectroscopic, and crystallographic methods. We concluded the electrostatic ligand–ligand interactions within Cu(II) and Pd(II) complexes containing an acidic and a basic amino acid and aromatic ring stacking interactions between the aromatic rings of an aromatic amino acid and a coordinated aromatic ligand such as 2,2′-bipyridine. Selective adduct formation between Pt(II) complexes and uncoordinated mononucleotides w...
影响因子：
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作者：
S. Burley;G. Petsko
通讯作者：
S. Burley;G. Petsko
影响因子：
56.9
作者：
PELLETIER, H;KRAUT, J
通讯作者：
KRAUT, J