Minimum alveolar concentration of volatile anesthetics in rats during postnatal maturation
Minimum alveolar concentration of volatile anesthetics in rats during postnatal maturation
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DOI：
10.1097/00000542-200109000-00028
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发表时间：
2001-09-01
期刊：
影响因子：
8.8
通讯作者：
Riou, B
中科院分区：
文献类型：
--
作者：
Orliaguet, G;Vivien, B;Riou, B
背景资料：尽管新生大鼠已被广泛用作实验室动物，但大鼠在出生后成熟期间挥发性麻醉剂的最小肺泡浓度（MAC）值仍然未知。测定了自主呼吸新生儿吸入麻醉药的MAC值，（2、9和30日龄）和成年Wistar大鼠暴露于（以0.1-0.2%的步长）氟烷、异氟烷或七氟烷的浓度（每组n = 12-20）。MAC及其95%置信区间采用Logistic回归计算，并根据体温进行校正结果：成年大鼠在37 ℃时的吸入MAC值为：氟烷，0.88%（置信区间，0.82-0.93%）;异氟烷，1.12%（1.07-1.18%）;七氟烷，1.97%（1.84-2.10%）。在30日龄大鼠中，数值如下：氟烷，1.14%（1.07-1.20%）;异氟烷，1.67%（1.58-1.76%）;七氟烷，2.95%（2.75-3.15%）。在9日龄大鼠中，吸入MAC值如下：氟烷，1.68%（1.58-1-78%）;异氟烷，2.34%（2.21-2.47%）;和七氟烷，3.74%（3.64-3.86%）。2日龄大鼠吸入的MAC值为：氟烷1.54%（1.44-1.64%）;异氟烷，1.86%（1.72-2.01%）和七氟烷，3.28%（3-09-3.47%）.结论：随着出生后日龄的增加，MAC值显著增加，在9日龄时达到最大值，此后下降，30日龄时仍大于成人MAC值。
Background: Although neonatal rats have become widely used as experimental laboratory animals, minimum alveolar concentration (MAC) values of volatile anesthetics in rats during postnatal maturation remain unknown.Methods: We determined MAC values of volatile anesthetics in spontaneously breathing neonatal (2-, 9-, and 30-day-old) and adult Wistar rats exposed to increasing (in 0.1-0.2% steps) concentrations of halothane, isoflurane, or sevoflurane (n = 12-20 in each group), using the tail-clamp technique. MAC and its 95% confidence inter-vats were calculated using logistic regression and corrected for body temperature (37 degreesC).Results: In adult rats, inspired MAC values corrected at 37 degreesC were as follows: halothane, 0.88% (confidence interval, 0.82-0.93%); isoflurane, 1.12% (1.07-1.18%); and sevoflurane, 1.97% (1.84-2.10%). In 30-day-old rats, the values were as follows: halothane, 1.14% (1.07-1.20%); isoflurane, 1.67% (1.58-1.76%); and sevoflurane, 2.95% (2.75-3.15%). in 9-day-old rats, inspired MAC values were as follows: halothane, 1.68% (1.58-1-78%); isoflurane, 2.34% (2.21-2.47%); and sevoflurane, 3.74% (3.64-3.86%). In 2-day-old rats, inspired MAC values were as follows: halothane, 1.54% (1.44-1.64%); isoflurane, 1.86% (1.72-2.01%); and sevoflurane, 3.28% (3-09-3.47%).Conclusion: As postnatal age increases, MAC value significantly increases, reaching the greatest value in 9-day-old rats, and decreases thereafter, and at 30 days is still greater than the adult MAC value.