Neuropathological abnormalities of the corpus callosum in schizophrenia: a diffusion tensor imaging study
Neuropathological abnormalities of the corpus callosum in schizophrenia: a diffusion tensor imaging study
复制标题
DOI：
10.1136/jnnp.68.2.242
复制
发表时间：
2000-02-01
影响因子：
11
通讯作者：
Ron, MA
中科院分区：
文献类型：
--
作者：
Foong, J;Maier, M;Ron, MA
目的：应用弥散张量成像（diffusion tensor imaging， DTI）技术研究精神分裂症患者体内胼胝体的神经病理学，该技术能够检测水在不同组织和白质束组织中的扩散。方法：对20例精神分裂症患者和25例健康对照进行弥散张量成像。从胼胝体的膝（前）和脾（后）的感兴趣区域获得了两个互补的指标，即平均扩散率和分数各向异性，这被认为是轴突完整性的敏感指标。结果：与对照组相比，精神分裂症组胼胝体脾脏的平均扩散率显著增加，分数各向异性显著减少，而非膝。精神分裂症患者和对照组的DTI测量没有明显的性别差异。临床变量如年龄、病程、抗精神病药物剂量和精神分裂症症状不能预测精神分裂症患者的DTI变化。结论：胼胝体的脾部而非膝部存在DTI改变，提示精神分裂症患者可能存在神经连通性的局灶性破坏。然而，这些发现并不排除胼胝体其他区域或白质其他区域异常的可能性，使用不同分析方法的进一步研究可能使我们能够澄清这一点。弥散张量成像是研究精神分裂症白质结构的一种有价值的工具。
Objectives-Diffusion tensor imaging (DTI), a technique capable of examining water diffusion in different tissues and the organisation of white matter tracts, was used to investigate the neuropathology of the corpus callosum in vivo in patients with schizophrenia.Methods-Diffusion tensor imaging was performed in 20 schizophrenic patients and 25 healthy controls. Two complementary measures, mean diffusivity and fractional anisotropy, which are considered to be sensitive indices of axonal integrity, were obtained from regions of interest in the genu (anterior) and splenium (posterior) of the corpus callosum.Results-Mean diffusivity was significantly increased and fractional anisotropy significantly reduced in the splenium but not the genu of the corpus callosum in the schizophrenic group compared with controls. There were no significant sex differences in the DTI measures for either the schizophrenic or control group. Clinical variables such as age, duration of illness, dose of antipsychotic medication, and schizophrenic symptoms did not predict the DTI changes in the schizophrenic patients.Conclusions-The presence of DTI changes in the splenium but not the genu of the corpus callosum suggests that there may be a focal disruption of commisural connectivity in schizophrenia. However, these findings do not exclude the possibility of abnormalities in other areas of the corpus callosum or other regions of white matter and further research using different methods of analysis may enable us to clarify this. Diffusion tensor imaging is a valuable tool in investigating the structure of white matter in schizophrenia.