Cortical thickness abnormalities in patients with first episode psychosis: a meta-analysis of psychoradiologic studies and replication in an independent sample.
Cortical thickness abnormalities in patients with first episode psychosis: a meta-analysis of psychoradiologic studies and replication in an independent sample.
复制标题
DOI：
10.1093/psyrad/kkab015
复制
发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Biswal BB
中科院分区：
文献类型：
--
作者：
Wen K;Zhao Y;Gong Q;Zhu Z;Li Q;Pan N;Fu S;Radua J;Vieta E;Kumar P;Kemp GJ;Biswal BB
首发精神病（FEP）患者的皮质厚度（CTh）异常经常被报道，但结果不一致。通过对已发表的全脑研究的荟萃分析，确定FEP患者中最一致的CTh变化。meta分析采用SDM （seed-based d mapping）软件获取FEP中最显著的区域CTh变化，并采用meta回归分析探讨人口统计学和临床特征的影响。荟萃分析结果在142例FEP患者和142例年龄和性别匹配的健康对照（hc）的独立样本中进行验证，使用顶点分析和感兴趣区域分析，并进行多次比较校正。荟萃分析发现，与hc相比，FEP患者的右侧中颞叶皮层（MTC）较低的CTh延伸至颞叶上皮层（STC）、脑岛和前扣带皮层（ACC）。未发现CTh变化与人口统计学或临床变量之间存在显著相关性。这些结果在独立数据集分析中得到了重复。本研究确定了FEP中皮层异常的稳健模式，并扩展了对FEP中灰质异常和病理机制的理解。
Abnormalities of cortical thickness (CTh) in patients with their first episode psychosis (FEP) have been frequently reported, but findings are inconsistent. To define the most consistent CTh changes in patients with FEP by meta-analysis of published whole-brain studies. The meta-analysis used seed-based d mapping (SDM) software to obtain the most prominent regional CTh changes in FEP, and meta-regression analyses to explore the effects of demographics and clinical characteristics. The meta-analysis results were verified in an independent sample of 142 FEP patients and 142 age- and sex-matched healthy controls (HCs), using both a vertex-wise and a region of interest analysis, with multiple comparisons correction. The meta-analysis identified lower CTh in the right middle temporal cortex (MTC) extending to superior temporal cortex (STC), insula, and anterior cingulate cortex (ACC) in FEP compared with HCs. No significant correlations were identified between CTh alterations and demographic or clinical variables. These results were replicated in the independent dataset analysis. This study identifies a robust pattern of cortical abnormalities in FEP and extends understanding of gray matter abnormalities and pathological mechanisms in FEP.