Hydrocortisone at stress-associated concentrations helps maintain human heart rate variability during subsequent endotoxin challenge.
Hydrocortisone at stress-associated concentrations helps maintain human heart rate variability during subsequent endotoxin challenge.
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DOI：
10.1016/j.jcrc.2011.01.009
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发表时间：
2011-12
影响因子：
3.7
通讯作者：
Yeager, Mark P.
中科院分区：
文献类型：
--
作者：
Rassias, Athos J.;Guyre, Paul M.;Yeager, Mark P.
We evaluated the differential impact of stress-associated versus high, pharmacologic concentrations of hydrocortisone pre-treatment on heart rate variability (HRV) during a subsequent systemic inflammatory stimulus. Healthy volunteers were randomized to receive placebo, hydrocortisone at 1.5 mcg/kg/min (STRESS), or at 3.0 mcg/kg/min (PHARM) as a six-hour infusion. The STRESS dose was chosen to replicate the condition of physiological adrenal cortical output during acute systemic stress. The PHARM dose was chosen to induce a supra-physiological concentration of cortisol. The next day all subjects received 2 ng/kg E. coli endotoxin (lipopolysaccharide, LPS). HRV was analyzed with the statistic Approximate Entropy (ApEn). A lower ApEn correlates with decreased HRV. At the three-hour nadir the decrease in ApEn in the STRESS group was significantly less compared to placebo (p<0.03), while ApEn in the PHARM group was not statistically different. We also found that the maximal decrease in ApEn preceded maximal increase in heart rate in all groups. The decrease in RR interval was maximal at 4 hours while the ApEn nadir was one hour earlier at 3 hours. Pretreatment with a stress dose of hydrocortisone but not a higher pharmacologic dose maintained a significantly higher ApEn after endotoxin exposure when compared to a placebo. In addition, decreases in ApEn preceded increases in HR.
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影响因子：
3.6
作者：
Chen, Wei-Lung;Chen, Jiann-Hwa;Lee, Liang-Shong
通讯作者：
Lee, Liang-Shong
影响因子：
3.6
作者：
Griffin, MP;O'Shea, TM;Moorman, JR
通讯作者：
Moorman, JR
影响因子：
3.6
作者：
Griffin, MP;O'Shea, TM;Moorman, JR
通讯作者：
Moorman, JR
影响因子：
8
作者：
Griffin, MP;Lake, DE;Moorman, JR
通讯作者：
Moorman, JR
影响因子：
8.8
作者：
Hanss, R;Bein, B;Tonner, PH
通讯作者：
Tonner, PH