Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
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DOI：
10.1016/s0168-3659(99)00248-5
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发表时间：
2000-03-01
影响因子：
10.8
通讯作者：
Hori, K
中科院分区：
文献类型：
--
作者：
Maeda, H;Wu, J;Hori, K
大多数实体瘤具有在正常组织或器官中未观察到的独特的病理生理学特征，例如广泛的血管生成和因此的过度脉管系统、缺陷的血管结构、受损的淋巴引流/恢复系统以及大量增加的渗透性介质的产生。现已观察到脂质和大分子药物的渗透性和滞留性增强（EPR）效应在实体瘤中普遍存在。首先，增强的血管通透性将维持足够的营养和氧气供应，以供肿瘤快速生长。EPR效应还为脂质或聚合物缀合的抗癌药物（如SMANCS和PK-1）更有选择性地靶向特纳提供了很好的机会。在本综述中，EPR效应的基本特征，特别是所涉及的因素，以及它的调制，以改善大分子药物的肿瘤。还描述了肿瘤特异性血管生理学。(C)2000 Elsevier Science B. V.保留所有权利。
Most solid tumors possess unique pathophysiological characteristics that are not observed in normal tissues or organs, such as extensive angiogenesis and hence hypervasculature, defective vascular architecture, impaired lymphatic drainage/recovery system, and greatly increased production of a number of permeability mediators. The phenomenon now known as the enhanced permeability and retention (EPR) effect fur lipid and macromolecular agents has been observed to be universal in solid tumors. Primarily, enhanced vascular permeability will sustain an adequate supply of nutrients and oxygen for rapid tumor growth. The EPR effect also provides a great opportunity for more selective targeting of lipid- or polymer-conjugated anticancer drugs, such as SMANCS and PK-1, to the turner. In the present review, the basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor. Tumor-specific vascular physiology is also described. (C) 2000 Elsevier Science B.V. All rights reserved.