Impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cutaneous wound healing.
Impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cutaneous wound healing.
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DOI：
10.1016/j.etp.2011.06.001
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Swanson HI
中科院分区：
文献类型：
--
作者：
Moirangthem V;Katz WS;Su W;Choi EY;Dingle RW;Zeigler GM;Everson WV;Jennings CD;Gong M;Swanson HI
2,3,7,8-四氯二苯并-对二恶英 (TCDD) 是一大类多卤代芳香烃的代表，是广泛存在的环境污染物。对实验动物或培养细胞施用 TCDD 会导致许多有据可查的不良反应。例如，在发育中的生物体中观察到的 TCDD 的影响表明，暴露于此类环境污染物会显着改变胚胎形态发生。然而，尚不清楚成年动物的组织再生是否会受到类似的影响。考虑到这一点，我们使用小鼠皮肤伤口愈合模型研究了 TCDD 暴露对伤口愈合的影响。我们的结果表明，TCDD 暴露并没有显着改变伤口闭合所需的时间。然而，在接受 TCDD 治疗的小鼠中，观察到愈合伤口的拉伸强度显着下降，这表明伤口愈合异常。免疫染色显示，暴露于 TCDD 增加了伤口愈合后期受伤组织内检测到的巨噬细胞数量。我们的研究结果支持这样的观点，即暴露于 TCDD 等环境污染物会促进受伤组织的炎症，破坏正常愈合并最终导致愈合不良的伤口。
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a representative of a large group of polyhalogenated aromatic hydrocarbons that are widespread environmental contaminants. Administration of TCDD to laboratory animals or cultured cells results in a number of adverse effects that are well documented. For example, the effects of TCDD observed in developing organisms indicate that exposure to this class of environmental contaminants significantly alters embryo morphogenesis. However, it is not clear whether tissue regeneration in adult animals may be similarly affected. With this in mind, we examined the impact of TCDD exposure on wound healing using a murine cutaneous wound healing model. Our results indicate that TCDD exposure did not significantly alter the time needed for wound closure. However, in the TCDD-treated mice, a significant decrease in tensile strength in the healed wounds was observed which is indicative of an aberrantly healed wound. Immunostaining revealed that exposure to TCDD increased the population of macrophages detected within the wounded tissue at the latter stages of wound healing. Our findings support the idea that exposure to environmental contaminants such as TCDD is proinflammatory in the wounded tissue, disrupts normal healing and ultimately produces in a poorly healed wound.
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影响因子：
2.9
作者：
Ballas, CB;Davidson, JM
通讯作者：
Davidson, JM
影响因子：
3.8
作者：
KERKVLIET, NI;OUGHTON, JA
通讯作者：
OUGHTON, JA
影响因子：
6
作者：
Eming, Sabine A.;Werner, Sabine;Roers, Axel
通讯作者：
Roers, Axel
DOI：
10.1038/sj.jidsymp.5650008
发表时间：
2006-09-01
影响因子：
--
作者：
Davis, George E.;Saunders, W. Brian
通讯作者：
Saunders, W. Brian
影响因子：
3.2
作者：
Ivnitski-Steele, I;Walker, MK
通讯作者：
Walker, MK