Shortwave Infrared Imaging with J-Aggregates Stabilized in Hollow Mesoporous Silica Nanoparticles
Shortwave Infrared Imaging with J-Aggregates Stabilized in Hollow Mesoporous Silica Nanoparticles
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DOI：
10.1021/jacs.9b05195
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发表时间：
2019-08-14
影响因子：
15
通讯作者：
Sletten, Ellen M.
中科院分区：
文献类型：
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作者：
Chen, Wei;Cheng, Chi-An;Sletten, Ellen M.
组织对短波红外（SWIR）光是半透明的，从而在该区域中呈现优越的光学成像上级。然而，光学SWIR成像的广泛使用受到限制，部分原因是缺乏吸收和发射1000 nm以上光的明亮的生物相容性造影剂。J-Aggregation提供了一种将稳定的近红外（NJR）荧光团转化为红移SWIR造影剂的方法。在这里，我们证明了近红外荧光团IR-140的J-聚集体可以在中空介孔二氧化硅纳米颗粒（HMSNs）内制备，从而产生吸收和发射SWIR光的纳米材料。聚乙二醇化HMSN内的J-聚集体在缓冲液中稳定数周，并能够在980 nm激发下进行体内高分辨率成像。
Tissue is translucent to shortwave infrared (SWIR) light, rendering optical imaging superior in this region. However, the widespread use of optical SWIR imaging has been limited, in part, by the lack of bright, biocompatible contrast agents that absorb and emit light above 1000 nm. J-Aggregation offers a means to transform stable, near-infrared (NJR) fluorophores into red-shifted SWIR contrast agents. Here we demonstrate that J-aggregates of NIR fluorophore IR-140 can be prepared inside hollow mesoporous silica nanoparticles (HMSNs) to result in nanomaterials that absorb and emit SWIR light. The J-aggregates inside PEGylated HMSNs are stable for multiple weeks in buffer and enable high resolution imaging in vivo with 980 nm excitation.