THE DETECTION OF ANTIBODIES AGAINST PESTE DES PETITS RUMINANTS VIRUS IN CATTLE, SHEEP AND GOATS AND THE POSSIBLE IMPLICATIONS TO RINDERPEST CONTROL PROGRAMS
THE DETECTION OF ANTIBODIES AGAINST PESTE DES PETITS RUMINANTS VIRUS IN CATTLE, SHEEP AND GOATS AND THE POSSIBLE IMPLICATIONS TO RINDERPEST CONTROL PROGRAMS
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DOI：
10.1017/s0950268800057599
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发表时间：
1994-02-01
影响因子：
4.2
通讯作者：
MCKAY, JA
中科院分区：
文献类型：
--
作者：
ANDERSON, J;MCKAY, JA
基于单克隆抗体的竞争性ELISA（C-ELISA）已用于牛、绵羊和山羊中牛瘟和小反刍兽疫（PPR）病毒抗体的特异性测定。在接种牛瘟疫苗之前和之后，对格兰比亚的绵羊和山羊的血清样品进行检查，表明PPR病毒的抗体可以阻止对牛瘟疫苗的免疫反应。来自尼日利亚和加纳的牛血清显示出抗PPR病毒抗体的高流行率，这可能解释了一些国家在实现抗牛瘟的高接种后免疫水平方面所经历的困难。由于抗PPR病毒的抗体对牛瘟病毒具有交叉中和和交叉保护作用，因此在存在抗PPR病毒抗体的情况下进一步接种疫苗可能是对国家资源的浪费。本文介绍了PPR病毒从绵羊和山羊向牛传播的血清学证据，并强调需要将PPR血清学纳入血清监测计划，以更好地指示国家群体免疫力。
Monoclonal antibody-based competitive ELISA (C-ELISA) have been used for the specific measurement of antibodies to both rinderpest and peste des petits ruminants (PPR) viruses in cattle, sheep and goats. Examination of serum samples from sheep and goats in Glambia, before and after vaccination with rinderpest vaccine, suggested that antibodies to PPR virus could prevent an immune response to the rinderpest vaccine. Cattle sera from Nigeria and Ghana showed a high prevalence of antibody against PPR virus which may explain the difficulty experienced in some countries in achieving high post-vaccination immunity levels against rinderpest. Because antibodies against PPR virus are both cross-neutralizing and cross-protective against rinderpest virus further vaccination in the presence of antibodies against PPR virus may be a waste of national resources. This paper presents serological evidence for the transmission of PPR virus from sheep and goats to cattle and highlights the need to include PPR serology in the sere-monitoring programme to give a better indication of national herd immunity.