Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressin.
Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressin.
复制标题
压力，性别和成瘾：皮质激素释放因子，催产素和精氨酸 - 瓦asopressin的潜在作用。
DOI：
10.1097/fbp.0000000000000049
复制
发表时间：
2014-09
影响因子：
1.6
通讯作者：
Cadet JL
中科院分区：
文献类型：
--
作者：
Bisagno V;Cadet JL
应激敏感性和性别是神经精神疾病发展的预测因素。生活压力不仅是成瘾的风险因素，而且也是复吸的诱因。因此，有必要阐明应激和药物滥用之间相互作用的分子机制，因为这种理解可能有助于开发新的和更有效的治疗方法来阻断药物成瘾的临床表现。成瘾相关疾病的发展和临床过程似乎确实涉及调节应激反应的神经回路内的神经适应，并受到几种神经肽的影响。这些包括促肾上腺皮质激素释放因子（CRF），这类的原型成员，以及催产素（OXY）和精氨酸加压素（AVP），在亲和行为中发挥重要作用。有趣的是，这些肽在OXY/AVP系统的性二态性中起到平衡情绪行为的作用，这一事实可能在女性和男性对压力刺激的不同反应以及某些成瘾性疾病的特定性别患病率中发挥重要作用。因此，本文旨在总结（1）性别差异对多巴胺系统功能的贡献，以及（2）大脑应激系统的行为，神经化学和解剖学变化。
Stress sensitivity and gender are predictive factors for the development of neuropsychiatric disorders. Life stresses are not only risk factors for the development of addiction but they are also triggers for relapse to drug use. Therefore, it is imperative to elucidate the molecular mechanisms underlying the interactions between stress and drug abuse, because this understanding may help in the development of novel and more effective therapeutic approaches to block the clinical manifestations of drug addiction. The development and clinical course of addiction-related disorders do appear to involve neuroadaptations within neurocircuitries that modulate stress responses and are influenced by several neuropeptides. These include corticotropin releasing factor (CRF), the prototypic member of this class, as well as oxytocin (OXY) and arginine-vasopressin (AVP) that play important roles in affiliative behaviors. Interestingly, these peptides function to balance emotional behaviors in a sexual dimorphism of OXY/AVP systems, a fact that might play an important role in the differential responses of women and men to stressful stimuli and the specific gender-based prevalence of certain addictive disorders. Thus, this review aims to summarize (1) the contribution of sex differences to the function of dopamine systems, and (2) the behavioral, neurochemical, and anatomical changes in brain stress systems.