Impulsive choice does not predict binge-like eating in rats.
Impulsive choice does not predict binge-like eating in rats.
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DOI：
10.1097/fbp.0000000000000446
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发表时间：
2018-12
影响因子：
1.6
通讯作者：
Cottone P
中科院分区：
文献类型：
--
作者：
Moore CF;Blasio A;Sabino V;Cottone P
暴饮暴食症（BED）是一种类似成瘾的疾病，其特征是在离散的时间段内反复过度进食，并且与性格冲动的增加有关。在冲动因素中，虽然冲动行为被证明可以预测暴饮暴食和成瘾行为，但冲动选择的作用却未知。这项研究的目的是确定冲动的选择是否预示着，或者被暴饮暴食的含糖、美味的食物所改变。我们利用一种改进的调整延迟任务（ADT）程序来评估自由喂养大鼠的冲动选择行为，即倾向于对较大的延迟奖励作出反应，而不是较小的即时奖励。我们发现，基线冲动选择并不能预测在1小时的可口饮食自我管理过程中暴饮暴食的行为。此外，暴饮暴食同样美味的食物对后来的冲动选择行为没有影响。因此，我们的数据表明，与冲动行为不同，冲动选择行为不能预测老鼠的暴饮暴食行为。
Binge eating disorder (BED) is an addiction-like disorder characterized by recurrent, excessive food consumption within discrete periods of time, and it has been linked to increased trait impulsivity. Within impulsivity components, while impulsive action was shown to predict binge- and addictive-like eating, the role of impulsive choice is instead unknown. The goal of this study was to determine if impulsive choice predicted, or was altered by, binge-like eating of a sugary, highly palatable diet. We utilized a modified adjusting delay task (ADT) procedure in ad libitum fed rats to assess impulsive choice behavior, i.e. the tendency to respond for a larger, delayed reward over a lesser, immediate reward. We found that baseline impulsive choice was not a predictor of binge-like eating in 1-hour sessions of palatable diet operant self-administration. Furthermore, binge-like eating of the same palatable diet had no effect on later impulsive choice behavior. Thus, our data suggest that, unlike impulsive action, impulsive choice behavior does not predict binge-like eating in rats.