Dopamine Agonist-Induced Impulse Control Disorders in Patients With Prolactinoma: A Cross-Sectional Multicenter Study
Dopamine Agonist-Induced Impulse Control Disorders in Patients With Prolactinoma: A Cross-Sectional Multicenter Study
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DOI：
10.1210/jc.2018-02202
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发表时间：
2019-07-01
影响因子：
5.8
通讯作者：
Yarman, Sema
中科院分区：
文献类型：
--
作者：
Dogansen, Sema Ciftci;Cikrikcili, Ugur;Yarman, Sema
内容：多巴胺激动剂（DA）诱导的冲动控制障碍（ICD）在泌乳素瘤患者中的作用尚不清楚。目的：评估DA诱导的ICD在泌乳素瘤患者中的患病率以及与这些疾病相关的可能危险因素。设计、设置和参与者：这是十字架部分多中心研究，包括308例催乳素瘤患者，在三级转诊中心接受至少3个月的DA治疗。DA诱导的ICD（病理性赌博、性欲亢进、强迫性购物和强迫性进食）和冲动性分别使用帕金森病冲动性强迫障碍问卷和Barratt冲动性量表-11进行评估。患者进行了评估，在ICD development.Results相关的参数：任何ICD患病率为17%（n = 51）。性欲亢进最常见（6.5%）。尽管任何ICD和性欲亢进在男性患者中更常见（分别为P = 0.009，P < 0.001），但强迫进食在女性患者中更常见（P = 0.046）。在任何ICD患者中，当前吸烟、饮酒和赌博史更常见（分别为P = 0.033、P = 0.002、P = 0.008）。在Barratt冲动量表-11总分中，任何ICD患者的注意力、运动和非计划得分均较高（P < 0.001）。目前吸烟和饮酒更频繁（P = 0.007，P = 0.003，分别）和百分比增加睾酮水平在最后一次访问是较高的（P = 0.021）在男性患者与催乳素瘤hypersexuality.Conclusion：任何ICD可以看到在6例泌乳素瘤谁正在接受DA治疗。内分泌专家应该意识到这种副作用，特别是在有赌博、吸烟或饮酒史的男性患者中。
Context: Dopamine agonist (DA)-induced impulse control disorder (ICD) in patients with prolactinomas is not sufficiently known.Objective: To evaluate the prevalence of DA-induced ICDs and possible risk factors related to these disorders in patients with prolactinoma.Design, Setting, and Participants: This is a cross-sectional multicenter study involving 308 patients with prolactinoma followed up in tertiary referral centers who received at least three months of DA therapy. DA-induced ICDs (pathological gambling, hypersexuality, compulsive shopping, and compulsive eating) and impulsivity were assessed using the Questionnaire for ImpulsiveCompulsive Disorders in Parkinson Disease and the Barratt Impulsiveness Scale-11, respectively. Patients were evaluated in terms of parameters related to ICD development.Results: Any ICD prevalence was 17% (n = 51). Hypersexuality was most common (6.5%). Although any ICD and hypersexuality were more common in male patients (P = 0.009, P < 0.001, respectively), compulsive eating was more common in female patients (P = 0.046). Current smoking, alcohol use, and gambling history were more frequent (P = 0.033, P = 0.002, P = 0.008, respectively) in patients with any ICD. In Barratt Impulsiveness Scale-11 total, attentional, motor, and nonplanning scores were higher in patients with any ICD (P < 0.001). Current smoking and alcohol use were more frequent (P = 0.007, P = 0.003, respectively) and percentage increase of testosterone levels at last visit was higher (P = 0.021) in male patients with prolactinomas with hypersexuality.Conclusion: Any ICD may be seen in one of six patients with prolactinoma who are receiving DA therapy. Endocrinology specialists should be aware of this side effect, particularly in male patients with a history of gambling, smoking, or alcohol use.