Disturbed function and plasticity in multiple sclerosis as gleaned from functional magnetic resonance imaging.
Disturbed function and plasticity in multiple sclerosis as gleaned from functional magnetic resonance imaging.
复制标题
从功能性磁共振成像中收集到的多发性硬化症的功能和可塑性受到干扰。
DOI：
10.1097/00019052-200306000-00005
复制
发表时间：
2003
影响因子：
4.8
通讯作者：
M. Rocca
中科院分区：
文献类型：
--
作者：
M. Filippi;M. Rocca
综述目的
这篇综述的目的是提供一个最新的总结的主要功能磁共振成像研究进行的多发性硬化症患者，并显示这些研究是如何改变我们的观点的能力，多发性硬化症的大脑，以限制不可逆的结构性组织损伤的临床后果。
最近的调查结果
脑皮质重组是多发性硬化患者的常见现象，与疾病持续时间和临床表型无关，可由肉眼可见的病变以及脑和颈髓的“隐匿性”多发性硬化相关损伤引起。参与特定任务执行的大脑网络的招募增加可能代表了皮质重组的第一步，具有在多发性硬化症过程中维持正常功能水平的潜力。这些机制的逐渐失效，因为累积的组织损伤，可能会导致，一方面，在激活以前沉默的“二级”补偿区，另一方面，有助于积累不可逆的残疾。
总结
功能性磁共振成像有可能提供有关多发性硬化相关组织损伤后皮质重组的重要信息，这将提高我们对这种疾病中与不可逆残疾积累相关的因素的理解。这种皮质适应性可塑性的任何有益作用的增强应被视为多发性硬化症治疗的潜在靶点。
PURPOSE OF REVIEW
This review is intended to provide an up-to-date summary of the main functional magnetic resonance imaging studies conducted in patients with multiple sclerosis, and to show how such studies are changing our views on the ability of the multiple sclerosis brain to limit the clinical consequences of irreversible structural tissue damage.
RECENT FINDINGS
Brain cortical reorganization is a common phenomenon occurring in patients with multiple sclerosis, independent of disease duration and clinical phenotype, which can be elicited by macroscopic lesions, as well as by the presence of 'occult' multiple sclerosis-related damage of the brain and cervical cord. An increased recruitment of the cerebral networks involved in the performance of given tasks might represent a first step in cortical reorganization with the potential to maintain a normal level of function in the course of multiple sclerosis. The progressive failure of these mechanisms, because of accumulating tissue damage, might, on the one hand, result in the activation of previously silent 'second-order' compensatory areas, and, on the other, contribute to the accumulation of irreversible disability.
SUMMARY
Functional magnetic resonance imaging has the potential to provide important information about cortical reorganization following multiple sclerosis-related tissue damage, which should improve our understanding of the factors associated with the accumulation of irreversible disability in this disease. The enhancement of any beneficial effects of this cortical adaptive plasticity should be considered as a potential target of therapy for multiple sclerosis.