Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.
复制标题
烷基甘油磷酸合酶对人甲状腺癌细胞系FRO中circRNA表达谱的影响
DOI：
10.3892/ol.2018.8356
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发表时间：
2018-05
期刊：
影响因子：
2.9
通讯作者：
Zhu Y
中科院分区：
文献类型：
--
作者：
Hou S;Tan J;Yang B;He L;Zhu Y
甲状腺癌是中国最常见的原发肿瘤。因此，研究甲状腺癌发生的分子机制对实现有效的个体化治疗具有重要意义。在我们先前的研究中，烷基甘油磷酸合成酶(AGPS)的表达与甲状腺癌细胞系的恶性表型呈正相关。AGPS失活能够降低肿瘤的恶性程度，抑制肿瘤的生长和侵袭。然而，AGPS在甲状腺癌中的作用尚不清楚。本研究揭示了AGPS能够调节环状RNAs的表达，这可能是其抗癌作用的机制。因此，本研究利用CircRNAs微阵列技术研究了AGPS沉默和基因敲除对甲状腺癌细胞株CircRNA表达的影响，并通过基因本体学和京都百科全书的基因和基因组途径富集化分析，探讨了AGPS通过CircRNAs调控甲状腺癌的分子机制。
Thyroid cancer is a common primary tumor in China. Therefore, it is important to investigate the underlying molecular mechanism of thyroid cancer in order to achieve effective individualized treatments. In our previous study, a positive correlation between the expression of alkylglycerone phosphate synthase (AGPS) and the malignant phenotype of thyroid cancer cell lines was identified. The inactivation of AGPS was able to decrease the malignancy of cancer, and inhibit tumor growth and invasion. However, the function of AGPS on thyroid cancer was unclear. In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed in order to investigate the underlying molecular mechanism of AGPS for the regulation of thyroid cancer through circRNAs.
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影响因子：
14.9
作者：
Ritchie ME;Phipson B;Wu D;Hu Y;Law CW;Shi W;Smyth GK
通讯作者：
Smyth GK
影响因子：
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作者：
Zhao, Liang;Sun, Hongwei;Zhou, Mengtao
通讯作者：
Zhou, Mengtao
影响因子：
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作者：
Zhu, Yu;Liu, Xing-Jun;Zhang, Ling
通讯作者：
Zhang, Ling
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影响因子：
2.9
作者：
Li Z;Zhao K;Tian H
通讯作者：
Tian H
影响因子：
14.8
作者：
Huang, Da Wei;Sherman, Brad T.;Lempicki, Richard A.
通讯作者：
Lempicki, Richard A.