The interface between metabolic and stress signalling
The interface between metabolic and stress signalling
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DOI：
10.1093/aob/mcp285
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发表时间：
2010-02-01
期刊：
影响因子：
4.2
通讯作者：
Halford, Nigel G.
中科院分区：
文献类型：
--
作者：
Hey, Sandra J.;Byrne, Edward;Halford, Nigel G.
越来越清楚的是，压力和代谢信号网络相互作用，这种相互作用是重要的植物响应植食性，病原体的攻击，干旱，寒冷，炎热和渗透胁迫，包括盐度。在这两个主要信号系统之间的界面是激素脱落酸（阿坝）和信号因子，包括蛋白激酶和转录因子。本文简要回顾了阿坝，胁迫和糖信号之间的联系，重点是蔗糖非发酵1相关蛋白激酶（SnRKs），SnRK 1激活蛋白激酶（SnAKs），钙依赖性蛋白激酶（CDPKs）和阿坝反应元件结合蛋白（AREBPs，它们是转录因子）。压力和氮/氨基酸信号之间的联系也进行了描述，包括蛋白激酶的作用，称为一般控制非去阻遏（GCN）-2调节蛋白质合成通过磷酸化的α-亚基的翻译起始因子-2（eIF 2 α），不仅在氨基酸水平的下降，但也范围内的压力。糖和氨基酸信号之间的联系的证据进行了探讨，硝酸还原酶是通过不同的机制调节SnRK 1和GCN 2的目标; SnRK 1和GCN 2之间可能的联系，通过一个途径，包括雷帕霉素（TOR）-1的蛋白激酶目标进行了描述。这些相互作用的信号网络的概念，而不是简单的级联和途径的意义，并在预测的范围内增加的严重程度和范围的压力，植物将不得不承受作为全球气候变化的结果的主题的重要性进行了讨论。
It is becoming increasingly clear that stress and metabolic signalling networks interact and that this interaction is important in plant responses to herbivory, pathogen attack, drought, cold, heat and osmotic stresses including salinity. At the interface between these two major signalling systems are the hormone abscisic acid (ABA) and signalling factors including protein kinases and transcription factors.This briefing reviews links between ABA, stress and sugar signalling, focusing on the roles of sucrose non-fermenting-1-related protein kinases (SnRKs), SnRK1-activating protein kinases (SnAKs), calcium-dependent protein kinases (CDPKs) and ABA response element binding proteins (AREBPs, which are transcription factors). Links between stress and nitrogen / amino acid signalling are also described, including the roles of a protein kinase called general control non-derepressible (GCN)-2 in regulating protein synthesis through phosphorylation of the alpha-subunit of translation initiation factor-2 (eIF2 alpha) in response not only to decreases in amino acid levels but also to a range of stresses. Evidence of a link between sugar and amino acid signalling is explored, with nitrate reductase being a target for regulation by both SnRK1 and GCN2 through different mechanisms; possible links between SnRK1 and GCN2 via a pathway including the protein kinase target of rapamycin (TOR)-1 are described. The significance of these interactions to the concept of signalling networks as opposed to simple cascades and pathways, and the importance of the subject in the context of the predicted increase in severity and range of stresses that plants will have to withstand as a result of global climate change are discussed.