Dietary carotenoids, serum β-carotene, and retinol and risk of lung cancer in the alpha-tocopherol, beta-carotene cohort study
Dietary carotenoids, serum β-carotene, and retinol and risk of lung cancer in the alpha-tocopherol, beta-carotene cohort study
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DOI：
10.1093/aje/kwf072
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发表时间：
2002-09-15
影响因子：
5
通讯作者：
Albanes, D
中科院分区：
文献类型：
--
作者：
Holick, CN;Michaud, DS;Albanes, D
几项β-胡萝卜素补充试验的结果出乎意料，与大多数观察性研究相冲突。在各种水果和蔬菜中发现了β-胡萝卜素以外的类胡萝卜素，可能在这种重要的恶性肿瘤中发挥作用，但以前关于五种主要类胡萝卜素的研究结果不一致。作者分析了饮食中β-胡萝卜素、β-胡萝卜素、叶黄素/玉米黄质、番茄红素、β-隐黄质、维生素A、血清β-胡萝卜素和血清视黄醇与1985年至1993年在芬兰西南部进行的男性吸烟者的α-生育酚、β-胡萝卜素癌症预防研究队列中肺癌风险之间的关系。在27，084名年龄在50-69岁之间的男性吸烟者中，在基线时完成了276种食物的饮食问卷调查，其中1，644人在长达14年的随访期间患上了肺癌。考克斯比例风险模型用于估计相对风险和95%置信区间。水果和蔬菜的消费与较低的肺癌风险相关（相对风险= 0.73，95%置信区间：0.62，0.86，最高与最低五分位数）。在番茄红素（28%）、叶黄素/玉米黄质（17%）、β-隐黄质（15%）、总类胡萝卜素（16%）、血清β-胡萝卜素（19%）和血清视黄醇（27%）的最高五分位数与最低五分位数中观察到肺癌风险较低。这些发现表明，大量食用水果和蔬菜，特别是富含类胡萝卜素、西红柿和西红柿制品的饮食，可能会降低患肺癌的风险。
Findings from several beta-carotene supplementation trials were unexpected and conflicted with most observational studies. Carotenoids other than beta-carotene are found in a variety of fruits and vegetables and may play a role in this important malignancy, but previous findings regarding the five major carotenoids are inconsistent. The authors analyzed the associations between dietary beta-carotene, beta-carotene, lutein/zeaxanthin, lycopene, beta-cryptoxanthin, vitamin A, serum beta-carotene, and serum retinol and the lung cancer risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of male smokers conducted in southwestern Finland between 1985 and 1993. Of the 27,084 male smokers aged 50-69 years who completed the 276-food item dietary questionnaire at baseline, 1,644 developed lung cancer during up to 14 years of follow-up. Cox proportional hazards models were used to estimate relative risks and 95% confidence intervals. Consumption of fruits and vegetables was associated with a lower lung cancer risk (relative risk = 0.73, 95% confidence interval: 0.62, 0.86, highest vs. lowest quintile). Lower risks of lung cancer were observed for the highest versus the lowest quintiles of lycopene (28%), lutein/zeaxanthin (17%), beta-cryptoxanthin (15%), total carotenoids (16%), serum beta-carotene (19%), and serum retinol (27%). These findings suggest that high fruit and vegetable consumption, particularly a diet rich in carotenoids, tomatoes, and tomato-based products, may reduce the risk of lung cancer.