Novel pharmacology of substance K-binding sites: a third type of tachykinin receptor.
Novel pharmacology of substance K-binding sites: a third type of tachykinin receptor.
复制标题
K 物质结合位点的新药理学：第三种速激肽受体。
作者：
S. H. Buck;E. Burcher;C. Shults;W. Lovenberg;T. O'Donohue
The tachykinins are a family of peptides with the carboxyl terminal amino acid sequence Phe-X-Gly-Leu-Met-NH2. Three major mammalian tachykinins have been identified--substance K, neuromedin K, and substance P--but only two tachykinin receptors have been postulated. Three tachykinins were labeled with radioiodinated Bolton-Hunter reagent and their binding characteristics were determined in crude membrane suspensions from several tissues. In cerebral cortex labeled eledoisin exhibited high-affinity binding that was inhibited by tachykinins in a manner indicating a definitive SP-E receptor site. In gastrointestinal smooth muscle and bladder, high-affinity binding of labeled substance P was inhibited in a pattern indicating a definitive SP-P site. In intestinal smooth muscle and bladder, however, labeled substance K and labeled eledoisin were both bound in a pattern indicating a preference for substance K itself. The results suggest the existence of three distinct types of tachykinin receptors: SP-P, SP-E, and SP-K.
3h-P物质与唾液腺膜结合。
影响因子：
3.6
作者：
Lee,CM;Javitch,JA;Snyder,SH
通讯作者：
Snyder,SH
通过药理学方法测定豚鼠回肠中 P 物质和 P 物质类似物的解离常数。
影响因子：
3.6
作者：
Lin,CW;Musacchio,JM
通讯作者：
Musacchio,JM