Development of a flow estimation and control system of an implantable centrifugal blood pump for circulatory assist.
Development of a flow estimation and control system of an implantable centrifugal blood pump for circulatory assist.
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开发用于循环辅助的植入式离心血泵的流量估计和控制系统。
DOI：
10.1046/j.1525-1594.1998.06130.x
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发表时间：
1998
影响因子：
2.4
通讯作者：
H. Takano
中科院分区：
文献类型：
--
作者：
Y. Wakisaka;Y. Okuzono;Y. Taenaka;K. Chikanari;S. Endo;T. Masuzawa;H. Takano
我所开发了一种用于植入式离心血泵（ICBP）的旁路流量估计和控制系统（BECS）。 ICBP的估计流量(EF)是根据电力消耗、电机的转速以及由血细胞比容和体温推定的血液粘度导出的。在 40 天的体内实验中，EF 的误差为 0.5 +/- 0.4 L/min。每 200 ms 自动控制电机转速，使 EF 与所需流量 (DF) 一致。在体外和体内实验中研究了 BECS 的反应性和准确性。 ICBP 由 BECS 在模拟电路中与脉动心室辅助装置 (PVAD) 并行操作，以模拟左心搭桥。通过在后负载 160/97 mm Hg 时将 DF 从 7 L/min 更改为 5 L/min 来评估反应性。为了评估 BECS 的准确性，在成年山羊（70 公斤）腹壁中的主动脉压力为 110/85 毫米汞柱的情况下驱动 ICBP。对于处于清醒状态的山羊，将 DF 设置为 5 L/min，持续 4 分钟。体外实验中改变流速需要13秒。 BECS 体内测得的流速 (MF) 保持在 5.0 +/- 0.2 L/min。总之，BECS 具有中等的反应性和准确性。
A bypass flow rate estimation and control system (BECS) for an implantable centrifugal blood pump (ICBP) has been developed in our institute. The estimated flow rate (EF) of the ICBP was derived from the electric power consumption, the rotating speed of a motor, and the blood viscosity presumed by the hematocrit and body temperature. The error in the EF was 0.5 +/- 0.4 L/min in in vivo experiments for 40 days. The rotating speed of the motor was controlled automatically every 200 ms to bring the EF in accord with the desired flow rate (DF). The reactivity and accuracy of the BECS were investigated in in vitro and in vivo experiments. The ICBP was operated by the BECS in a mock circuit in parallel with a pulsatile ventricular assist device (PVAD) to simulate left heart bypass. The reactivity was evaluated by changing the DF from 7 L/min to 5 L/min at an afterload of 160/97 mm Hg. To evaluate the accuracy of the BECS, the ICBP was driven under the aortic pressure of 110/85 mm Hg in the abdominal wall of an adult goat (70 kg). The DF was set at 5 L/min for 4 min for the goat in an awake condition. It took 13 s to change the flow rate in the in vitro experiment. The measured flow rate (MF) was maintained at 5.0 +/- 0.2 L/min by the BECS in vivo. In conclusion, the BECS has moderate reactivity and accuracy.