An in vitro porcine model evaluating a novel stent retriever for thrombectomy of the common carotid artery
An in vitro porcine model evaluating a novel stent retriever for thrombectomy of the common carotid artery
复制标题
体外猪模型评估用于颈总动脉血栓切除术的新型支架取回器。
DOI：
10.1002/ccd.26285
复制
发表时间：
2016-02-15
影响因子：
2.3
通讯作者：
Liu, Xinfeng
中科院分区：
文献类型：
--
作者：
Jiang, Yongjun;Li, Yun;Liu, Xinfeng
目的本研究旨在在猪模型中测试新型支架取栓器RECO的安全性和有效性。背景支架取栓器对急性缺血性中风患者表现出巨大的益处。方法对支架的框架进行优化。关闭近端支架;机械连接取代电解连接和位于纵轴上的推送金属丝。在体外试验后，通过血管造影和组织学分析评价RECO装置的安全性和血栓切除效率，在猪模型与放置实验性软或硬thrombi.ResultsNo设备相关的血栓观察围手术期或1个月后。内皮细胞完整，平滑肌细胞未迁移或增殖。在接受手术的9%血管中检测到器械相关血管痉挛，并在输送一定剂量的硝酸甘油后缓解。RECO器械在靶血管中表现出较高的再通率，平均为1.3次运行。结论RECO装置是一种新型、安全、有效的支架型血栓取栓器。正在进行IIa期临床试验RESTORE（NCT 01983644）。(c)2015 Wiley Periodicals，Inc.
ObjectivesThis study aimed to test the safety and efficiency of a novel stent retriever, RECO, in a swine model.BackgroundThe stent retrievers show great benefit for patients with acute ischemic stroke.MethodsThe framework of the stent was optimized. The proximal stent was closed; mechanical connection replaced the electrolysis connection and the push wire located on the longitudinal axis. After tests in vitro, the safety and thrombectomy efficiency of RECO device were evaluated by angiography and histological analysis in a swine model with placement of experimental soft or hard thrombi.ResultsNo device-related thrombi were observed on the perioperative term or 1 month later. The endothelial cells were intact and the smooth muscle cells did not migrate or proliferate. Device-related vasospasm was detected in 9% vessels undergoing the procedure and was alleviated after delivery of a dose of nitroglycerin. The RECO device demonstrated a high recanalization rate in the target vessels with a mean of 1.3 runs. No residual thrombi were observed under the DSA or microscope.ConclusionsOur data indicated that RECO device was a novel, safe and effective stent based clot retriever. A phase IIa clinical trial, RESTORE, is undergoing (NCT01983644). (c) 2015 Wiley Periodicals, Inc.