NEC Density and Liver ROI S/N Ratio for Image Quality Control of Whole-Body FDG-PET Scans: Comparison with Visual Assessment
NEC Density and Liver ROI S/N Ratio for Image Quality Control of Whole-Body FDG-PET Scans: Comparison with Visual Assessment
复制标题
DOI：
10.1007/s11307-009-0214-3
复制
发表时间：
2009-11-01
影响因子：
3.1
通讯作者：
Shiomi, Susumu
中科院分区：
文献类型：
--
作者：
Mizuta, Tetsuro;Senda, Michio;Shiomi, Susumu
目的：患者噪声当量计数（NEC）、NEC密度和肝脏感兴趣区域（ROI） S/N已被提出作为图像质量的物理指标，但尚未与视觉评估进行彻底的比较。在这项研究中，这些指标与在各种扫描条件和体重下获得的全身氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）图像的盲视觉评价进行了对比。方法：使用SET-3000B/L PET扫描仪对15名正常受试者进行连续床上运动成像。体重从50.2到95.7 kg不等，注射活度从71到333 MBq不等（1.40到3.67 MBq/kg），扫描时间从10到30分钟不等。患者NEC （PNEC；计数/cm）计算为NEC率除以床速。NEC密度（计数/cm(3)）定义为PNEC除以传输数据得出的横截面积。从颈部到腹部取PNEC和NEC密度平均值。肝脏S/N作为ROI内的像素均值/SD。由18名专业人士进行的盲评用于视觉评价图像质量。结果：平均视觉评分与肝脏S/N、PNEC、NEC密度相关，等级相关系数分别为0.81、0.86、0.91 （p < 0.05）
Purpose: Patient noise equivalent count (NEC), NEC density, and liver region of interest (ROI) S/N have been proposed as physical indicators of image quality, but have not been thoroughly compared with visual assessments. In this study, those indicators were contrasted with blind visual evaluations for whole-body fluorodeoxyglucose-positron emission tomography (FDG-PET) images acquired under a variety of scanning conditions and body weights.Methods: Images were acquired on 15 normal subjects using a SET-3000B/L PET scanner with a continuous bed motion. Body weight ranged from 50.2 to 95.7 kg, with injected activity ranging from 71 to 333 MBq (1.40 to 3.67 MBq/kg) and a scan duration from 10 to 30 min. Patient NEC (PNEC; counts/cm) was calculated as the NEC rate divided by bed speed. NEC density (counts/cm(3)) was defined as the PNEC divided by the cross-sectional area derived from transmission data. Both PNEC and NEC density were averaged from neck to abdomen. Liver S/N was obtained as the pixel mean/SD within the ROI. Blind reviews by 18 professionals were used to visually evaluate image quality.Results: Average visual score correlated with liver S/N, PNEC, and NEC density, with a rank correlation coefficient of 0.81, 0.86, and 0.91, respectively (each p