ESTIMATION OF WALL SHEAR STRESS USING 4D FLOW CARDIOVASCULAR MRI AND COMPUTATIONAL FLUID DYNAMICS
ESTIMATION OF WALL SHEAR STRESS USING 4D FLOW CARDIOVASCULAR MRI AND COMPUTATIONAL FLUID DYNAMICS
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DOI：
10.1142/s0219519417500464
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发表时间：
2017-05-01
影响因子：
0.8
通讯作者：
Castilla, R.
中科院分区：
文献类型：
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作者：
Soudah, E.;Casacuberta, J.;Castilla, R.
近几年来，壁面切应力（WSS）作为一种新的诊断指标在动脉疾病的患者中出现。大量证据表明，WSS与血流动力学指标一起在血管疾病的发生和发展中起着重要作用。因此，WSS值的估计可能具有临床意义，其测量方法对临床社区至关重要。近来，四维（4D）流心血管磁共振（CMR）已经被广泛地用于血流的可视化和量化的许多应用中，并且尽管对血流测量的灵敏度已经增加，但是还不能提供准确的三维（3D）WSS分布。本研究的目的是通过结合4D心血管磁共振（4D CMR）和计算流体力学（CFD）技术来评价主动脉血流特征和相关的WSS。特别是，在这项工作中，我们使用的4D CMR获得的空间域和边界条件需要估计整个胸主动脉内的WSS使用计算流体动力学。模拟的情况下，发现类似的WSS分布。进行了灵敏度分析，以检查该方法的准确性。4D CMR开始成为使用计算流体动力学估计整个胸主动脉内WSS的可靠工具。这两种技术的结合可以提供理想的工具，以帮助解决这些问题和其他有关的壁剪力估计。
In the last few years, wall shear stress (WSS) has arisen as a new diagnostic indicator in patients with arterial disease. There is a substantial evidence that the WSS plays a significant role, together with hemodynamic indicators, in initiation and progression of the vascular diseases. Estimation of WSS values, therefore, may be of clinical significance and the methods employed for its measurement are crucial for clinical community. Recently, four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) has been widely used in a number of applications for visualization and quantification of blood flow, and although the sensitivity to blood flow measurement has increased, it is not yet able to provide an accurate three-dimensional (3D) WSS distribution. The aim of this work is to evaluate the aortic blood flow features and the associated WSS by the combination of 4D flow cardiovascular magnetic resonance (4D CMR) and computational fluid dynamics technique. In particular, in this work, we used the 4D CMR to obtain the spatial domain and the boundary conditions needed to estimate the WSS within the entire thoracic aorta using computational fluid dynamics. Similar WSS distributions were found for cases simulated. A sensitivity analysis was done to check the accuracy of the method. 4D CMR begins to be a reliable tool to estimate the WSS within the entire thoracic aorta using computational fluid dynamics. The combination of both techniques may provide the ideal tool to help tackle these and other problems related to wall shear estimation.