EVALUATION OF VARICELLA-ZOSTER IMMUNE GLOBULIN - PROTECTION OF IMMUNOSUPPRESSED CHILDREN AFTER HOUSEHOLD EXPOSURE TO VARICELLA
EVALUATION OF VARICELLA-ZOSTER IMMUNE GLOBULIN - PROTECTION OF IMMUNOSUPPRESSED CHILDREN AFTER HOUSEHOLD EXPOSURE TO VARICELLA
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DOI：
10.1093/infdis/147.4.737
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发表时间：
1983-01-01
影响因子：
6.4
通讯作者：
LEGORE, J
中科院分区：
文献类型：
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作者：
ZAIA, JA;LEVIN, MJ;LEGORE, J
采用双盲随机临床试验方法，对水痘-带状疱疹病毒(VZV)抗体效价较高的正常供者血浆制备的水痘-带状疱疹免疫球蛋白(VZIG)和带状疱疹恢复期供者血浆制备的带状疱疹免疫球蛋白(ZIG)进行比较，以确定其对严重水痘免疫抑制儿童的保护作用。81例VZIG患者中49例(60.4%)发生VZV感染，83例ZIG患者中57例(68.6%)发生VZV感染。这些发病率和水痘的临床严重程度没有显著差异；ZIG受者的亚临床感染率显著高于ZIG受者(31.3%对16.0%)。这一差异是由接受非肿瘤性疾病免疫抑制治疗的患者亚组解释的。VZIG剂量加倍可降低亚临床感染率。可见，VZIG可用于保护免疫功能低下的儿童免受严重水痘的侵袭。
Varicella-zoster immune globulin (VZIG), an Ig prepared from normal donor plasma selected for high titer of antibody to varicella-zoster virus (VZV), and zoster immune globulin (ZIG), prepared from the plasma of donors convalescing from herpes zoster, were compared in a double-blind, randomized clinical trial to determine their relative efficacy in protecting immunosuppressed children from severe varicella. VZV infection occurred in 49 (60.4%) of 81 recipients of VZIG and in 57 (68.6%) of 83 recipients of ZIG. These rates and the clinical severity of varicella were not significantly different; the subclinical infection rate was significantly higher in ZIG recipients (31.3% vs. 16.0%). This difference was accounted for by a subgroup of patients receiving immunosuppressive therapy for nonneoplastic diseases. Doubling the dose of VZIG administered reduced the rate of subclinical infection. Evidently, VZIG can be used to protect immunosuppressed children from severe chicken pox.