The green tea polyphenolic catechin epigallocatechin gallate and neuroprotection
The green tea polyphenolic catechin epigallocatechin gallate and neuroprotection
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DOI：
10.1080/1028415x.2018.1500124
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发表时间：
2020-04-02
影响因子：
3.6
通讯作者：
Khademi, Emad
中科院分区：
文献类型：
--
作者：
Khalatbary, Ali Reza;Khademi, Emad
表没食子儿茶素没食子酸酯是茶儿茶素中含量最丰富的成分，被认为是绿茶提取物的主要生物活性的来源，如抗氧化、抗炎和抗凋亡作用。同时，EGCG已被证明对神经损伤和神经退行性疾病具有一定的神经保护作用。本文综述了EGCG的神经保护作用及其在各种神经退行性变和神经损伤模型中发挥神经保护作用的分子机制。
Epigallocatechin gallate is the most abundant composition of the tea catechins and is thought to be responsible for the majority of biological activity of green tea extracts such as antioxidant, anti-inflammatory, and antiapoptotic effects. Meanwhile, EGCG has been shown to be some of the neuroprotective effects against neural injuries and neurodegenerative diseases. This paper summarizes current knowledge on neuroprotective effects of EGCG and their molecular mechanisms responsible for the neuroprotection in various models of neurodegenerative and neural injury.