REVERSAL OF CARDIOPULMONARY FAILURE DURING ACTIVE SLEEP IN HYPOXIC KITTENS - IMPLICATIONS FOR SUDDEN INFANT DEATH
REVERSAL OF CARDIOPULMONARY FAILURE DURING ACTIVE SLEEP IN HYPOXIC KITTENS - IMPLICATIONS FOR SUDDEN INFANT DEATH
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DOI：
10.1126/science.910138
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发表时间：
1977-01-01
期刊：
影响因子：
56.9
通讯作者：
MCGINTY, DJ
中科院分区：
文献类型：
--
作者：
BAKER, TL;MCGINTY, DJ
实验诱导的小猫在安静睡眠、清醒和过渡状态下呼吸抑制和心功能不规律的发作。积极睡眠的开始刺激了呼吸和心率，并减少了这些功能的异常变异性。低氧显著降低了活跃睡眠的比例。积极的睡眠显然可以预防人类婴儿的呼吸和心脏异常。慢性低氧血症或其他减少婴儿活跃睡眠的因素，包括这种状态下的正常发育减退，可能会增加心肺衰竭和死亡的风险。
Experimentally induced hypoxia in kittens precipitated episodes of depressed respiration and irregular cardiac function during quiet sleep, waking and transitional states. The onset of active sleep stimulated both breathing and heart rate and decreased abnormal variability in these functions. Hypoxia markedly reduced the proportion of active sleep. Active sleep apparently protects against respiratory and cardiac abnormalities in human infants. Chronic hypoxemia or other factors that reduce active sleep in infants, including the normal developmental decrement in this state, may increase the risk of cardiopulmonary failure and death.