Suicidal ideation and suicide plans or attempts in adults with Asperger's syndrome attending a specialist diagnostic clinic: a clinical cohort study
Suicidal ideation and suicide plans or attempts in adults with Asperger's syndrome attending a specialist diagnostic clinic: a clinical cohort study
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DOI：
10.1016/s2215-0366(14)70248-2
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发表时间：
2014-07-01
影响因子：
64.3
通讯作者：
Baron-Cohen, Simon
中科院分区：
文献类型：
--
作者：
Cassidy, Sarah;Bradley, Paul;Baron-Cohen, Simon
背景成年期的艾氏综合征常与抑郁症相关，但很少有研究探讨这一临床群体自我报告的自杀意念和自杀计划或企图的终生经历。我们的目的是评估这种患病率在临床队列的患者在UK.Method在临床队列研究中，我们进行了回顾性分析，从成人新诊断的临床调查数据，在2004年1月23日和2013年7月8日之间，在英格兰的专科诊断诊所与Alfreger综合征。患者在临床评估前完成了一份自我报告问卷，记录了抑郁、自杀意念、自杀计划或企图的一生经历，沿着自我报告的自闭症特征和同情心的测量。我们将样本中自杀意念的发生率与一般人群和其他临床人群中自杀意念的发生率进行了比较。我们还评估了抑郁症，自闭症特征，同情心，自杀意念和自杀计划或attempts.Findings的可能性之间的关联374成人（256名男性和118名女性）被诊断为在研究期间与Alfreger综合征。367名受访者中有243名（66%）自我报告有自杀意念，365名受访者中有127名（35%）自我报告有自杀计划或企图，368名受访者中有116名（31%）自我报告有抑郁症。与英国一般人群样本相比，患有Alfreger综合征的成年人更有可能报告终生自杀意念经历（比值比9.6 [95% CI 7.6-11.9]，p < 0.0001），患有一种、两种或多种医学疾病的人（p < 0.0001），0001），或精神病患者（p = 0.019）。与被诊断为无抑郁症的人相比，有抑郁症的人更容易报告自杀意念（p < 0.0001）和自杀计划或企图（p < 0.0001）.解释我们的研究结果支持了关于患有Alfreger综合征的成年人自杀意念率增加的轶事报道，抑郁症是成年人自杀的重要潜在危险因素。由于患有Alfreger综合征的成年人通常有许多继发性抑郁症的危险因素（例如，社会孤立或排斥，以及失业），我们的研究结果强调需要适当的服务计划和支持，以降低这一临床群体的风险。版权所有（C）Cassidy et al.
Background Asperger's syndrome in adulthood is frequently associated with depression, but few studies have explored the lifetime experience of self-reported suicidal ideation and suicide plans or attempts in this clinical group. We aimed to assess this prevalence in a clinical cohort of patients in the UK.Method In a clinical cohort study, we undertook a retrospective analysis of clinical survey data from adults newly diagnosed with Asperger's syndrome at a specialist diagnostic clinic between Jan 23, 2004, and July 8, 2013, in England. Patients completed a self-report questionnaire before clinical assessment, recording lifetime experience of depression, suicidal ideation, and suicide plans or attempts, along with self-reported measures of autistic traits and empathy. We compared the rate of suicidal ideation in the sample with published rates of suicidal ideation in the general population and other clinical groups. We also assessed associations between depression, autistic traits, empathy, and likelihood of suicidal ideation and suicide plans or attempts.Findings 374 adults (256 men and 118 women) were diagnosed with Asperger's syndrome in the study period. 243 (66%) of 367 respondents self-reported suicidal ideation, 127 (35%) of 365 respondents self-reported plans or attempts at suicide, and 116 (31%) of 368 respondents self-reported depression. Adults with Asperger's syndrome were significantly more likely to report lifetime experience of suicidal ideation than were individuals from a general UK population sample (odds ratio 9.6 [95% CI 7.6-11.9], p < 0.0001), people with one, two, or more medical illnesses (p < 0. 0001), or people with psychotic illness (p = 0.019). Compared with people diagnosed with Asperger's syndrome without depression, people with Asperger's syndrome and depression were more likely to report suicidal ideation (p < 0.0001) and suicide plans or attempts (p < 0.0001).Interpretation Our findings lend support to anecdotal reports of increased rates of suicidal ideation in adults with Asperger's syndrome, and depression as an important potential risk factor for suicidality in adults with this condition. Because adults with Asperger's syndrome often have many risk factors for secondary depression (eg, social isolation or exclusion, and unemployment), our findings emphasise the need for appropriate service planning and support to reduce risk in this clinical group. Copyright (C) Cassidy et al.