Structural and antigenic studies of cockroach allergens and their relevance to asthma.
Structural and antigenic studies of cockroach allergens and their relevance to asthma.
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DOI：
10.1007/978-1-4615-5855-2_13
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发表时间：
1996
影响因子：
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通讯作者：
M. Chapman;L. Vailes;M. Hayden;D. Benjamin;T. Platts-Mills;L. Arruda
中科院分区：
文献类型：
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作者：
M. Chapman;L. Vailes;M. Hayden;D. Benjamin;T. Platts-Mills;L. Arruda
30多年前，Bernton和Brown在纽约的过敏诊所就诊的患者中首次描述了对蟑螂的过敏反应（CR）（1）。几个研究小组，特别是20世纪70年代芝加哥的Kang博士及其同事，对这些观察结果进行了跟踪研究，现在已经确定CR引起IgE抗体反应;这些反应通常与哮喘有关;并且CR哮喘在美国某些人群中的患病率与其他常见的空气过敏原如尘螨、猫和花粉的患病率相当（2，3）。生活在CR感染房屋中的特应性个体通过吸入强效CR过敏原而致敏，并产生强烈的IgE抗体（ab）反应。IgE ab发展为CR与哮喘之间存在强相关性。在美国的一些城镇，高达60%的室内灰尘过敏性哮喘患者对CR敏感（2-6）。对CR的过敏反应并不局限于城市或内城人群，而是发生在住房条件维持广泛蟑螂侵扰的地方。例如，在肯塔基州的路易斯维尔，居住在内城或农村地区的患者中CR过敏的患病率没有差异，在一项10年回顾性研究中报告了两组患者中阳性皮肤试验反应性的患病率均超过40%（7）。IgE ab至CR是哮喘急诊室入院的重要风险因素，最常见于居住在低于标准住房的较低社会经济群体，在美国，这些群体通常包括高比例的少数群体（非洲裔美国人和西班牙裔美国人（8-9））。
Allergic reactions to cockroach (CR) were first described over 30 years ago by Bernton and Brown, amongst patients presenting to their allergy clinic in New York (1). These observations were followed up by several groups, notably by Dr. Kang and colleagues in Chicago in the 1970’s, and it is now well established that CR cause IgE antibody responses; that these responses are often associated with asthma; and that the prevalence of CR asthma in some populations in the U.S. is comparable to that of other common aeroallergens, such as dust mite, cat, and pollens (2, 3). Atopic individuals who live in CR infested housing become sensitized by inhalation of potent CR allergens and produce vigorous IgE antibody (ab) responses. There is a strong association between the development of IgE ab to CR and asthma. In some towns and cities in the U.S., up to 60% of house dust allergic, asthmatic patients become sensitized to CR (2–6). Allergic reactions to CR are not confined to urban or inner city populations, but occur wherever housing conditions sustain extensive cockroach infestation. For example, in Louisville, Kentucky, no differences were found between the prevalence of CR allergy in patients living in inner city or rural areas, with ∼40% prevalence of positive skin test reactivity in both groups being reported in a 10 year retrospective study (7). IgE ab to CR is an important risk factor for Emergency Room admission with asthma and is most commonly found among lower socio economic groups living in sub-standard housing, which in the U.S. often comprise a high proportion of minority groups (African Americans and Hispanics (8–9).