Asymmetric inhibitory connections enhance directional selectivity in a three-layer simulation model of retinal networks.
Asymmetric inhibitory connections enhance directional selectivity in a three-layer simulation model of retinal networks.
复制标题
不对称抑制连接增强了视网膜网络三层模拟模型中的方向选择性。
DOI：
10.1142/s0219635210002469
复制
发表时间：
2010
影响因子：
1.8
通讯作者：
H. Takayasu
中科院分区：
文献类型：
--
作者：
A. Koizumi;M. Takayasu;H. Takayasu
在本文中，我们通过神经元模拟器重建六边形排列的视网膜三层模拟模型，发现兴奋性连接的空间和时间不对称性能够产生方向选择性，并且可以通过不对称抑制连接来增强方向选择性。对具有随机树突的神经节细胞的不对称兴奋性输入能够对速度小于 10 μm/msec 的移动刺激产生较弱的方向选择性。通过抑制性无长突细胞添加不对称抑制连接，方向选择性变得更强，能够以十倍快的速度（< 100 μm/msec）响应移动刺激。总之，兴奋机制似乎产生方向选择性，而不对称抑制连接增强视网膜的方向选择性。
In this paper, we found that spatial and temporal asymmetricity of excitatory connections are able to generate directional selectivity which can be enhanced by asymmetrical inhibitory connections by reconstructing a hexagonally-arranged three-layered simulation model of retina by NEURON simulator. Asymmetric excitatory inputs to ganglion cells with randomly arborizing dendrites were able to generate weaker directional selectivity to moving stimuli whose speed was less than 10 μm/msec. By just adding asymmetric inhibitory connections via inhibitory amacrine cells, directional selectivity became stronger to respond to moving stimuli at ten times faster speed (< 100 μm/msec). In conclusion, an excitatory mechanism appeared to generate directional selectivity while asymmetric inhibitory connections enhance directional selectivity in retina.
培养的大鼠无长突细胞的动作电位从体细胞到单个树突的传播受到局部 GABA 输入的独立调节
DOI：
--
发表时间：
2002
期刊：
J.Neurophysiol. 87
影响因子：
--
作者：
Yamada;Y.;Koizumi;A.;Iwasaki;E.;Watanabe;S.-I.;Kaneko;A.
通讯作者：
A.