Virological and cellular roles of the transcriptional coactivator LEDGF/p75.
Virological and cellular roles of the transcriptional coactivator LEDGF/p75.
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DOI:
10.1007/978-3-642-02175-6_7
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发表时间:
2009
影响因子:
--
通讯作者:
Poeschla, Eric M.
中科院分区:
文献类型:
--
作者:
Llano, Manuel;Morrison, James;Poeschla, Eric M.
The chromatin associated cellular proteins LEDGF/p75 and LEDGF/p52 have been implicated in transcriptional regulation, cell survival and autoimmunity. LEDGF/p75 also appears to act as a chromatin docking factor or receptor for HIV-1 and other lentiviruses and also to play a role in leukemogenesis. For both the viral and cellular roles of this protein, a key feature is its ability to act as a molecular adaptor and tether proteins to the chromatin fiber. This chapter reviews the emerging roles of LEDGF/p75 and LEDGF/p52 in diverse cellular processes and disease states.
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