Mechanism of action of calcium-channel-blocking agents.
Mechanism of action of calcium-channel-blocking agents.
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DOI：
10.1056/nejm198212233072605
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发表时间：
1982-12
期刊：
影响因子：
--
通讯作者：
E. Braunwald
中科院分区：
文献类型：
--
作者：
E. Braunwald
钙离子（Ca++）在许多生物过程中都是至关重要的，包括各种酶促反应、可兴奋细胞的激活、电激活与细胞分泌的耦合、止血和骨代谢。干扰钙离子进入细胞的药物的开发——各种各样的钙离子通道阻滞剂、钙离子进入阻滞剂、钙离子拮抗剂和慢通道阻滞剂——为基础科学家研究钙离子在正常和病理状态下的作用提供了强大的新工具，并为临床医生提供了几种重要的新的治疗药物用于治疗癌症。
Calcium ions (Ca++) are vital in many biologic processes, including a variety of enzymatic reactions, activation of excitable cells, coupling of electrical activation to cellular secretion, hemostasis, and the metabolism of bone. The development of drugs that interfere with the entry of Ca++ into cells — variously termed Ca++-channel blockers, Ca++-entry blockers, Ca++ antagonists, and slow-channel blockers — has provided the basic scientist with powerful new tools for the study of the role of this ion in normal as well as pathologic states and has provided the clinician with several important new therapeutic agents for use in . . .