Meiotic drive of female-inherited supernumerary chromosomes in a pathogenic fungus
Meiotic drive of female-inherited supernumerary chromosomes in a pathogenic fungus
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DOI：
10.7554/elife.40251
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发表时间：
2018-12-13
期刊：
影响因子：
7.7
通讯作者：
Stukenbrock, Eva Holtgrewe
中科院分区：
文献类型：
--
作者：
Habig, Michael;Kema, Gert H. J.;Stukenbrock, Eva Holtgrewe
减数分裂是有性生殖的关键细胞过程，包括同源序列的配对。然而，在许多物种中，减数分裂也可能涉及额外染色体的分离，这可能缺乏同源体。这些未配对的染色体如何进行减数分裂在很大程度上是未知的。在这项研究中，我们调查了染色体分离减数分裂过程中的单倍体真菌Zymoseptoria triumphoria，拥有大量的额外染色体。我们使用等基因的全染色体缺失菌株比较配对和不配对时染色体的减数分裂传递。从父本遗传的不成对染色体以及成对的额外染色体一般表现为孟德尔遗传。相反，从母本遗传的未配对染色体显示非孟德尔遗传，但被扩增并传递到所有减数分裂产物。我们认为，Z.三倍体显示减数分裂驱动，并提出减数分裂期间的额外反馈机制，其启动未配对的雌性遗传染色体的扩增。
Meiosis is a key cellular process of sexual reproduction that includes pairing of homologous sequences. In many species however, meiosis can also involve the segregation of supernumerary chromosomes, which can lack a homolog. How these unpaired chromosomes undergo meiosis is largely unknown. In this study we investigated chromosome segregation during meiosis in the haploid fungus Zymoseptoria tritici that possesses a large complement of supernumerary chromosomes. We used isogenic whole chromosome deletion strains to compare meiotic transmission of chromosomes when paired and unpaired. Unpaired chromosomes inherited from the male parent as well as paired supernumerary chromosomes in general showed Mendelian inheritance. In contrast, unpaired chromosomes inherited from the female parent showed non-Mendelian inheritance but were amplified and transmitted to all meiotic products. We concluded that the supernumerary chromosomes of Z. tritici show a meiotic drive and propose an additional feedback mechanism during meiosis, which initiates amplification of unpaired female-inherited chromosomes.