PRESSOR REFLEX EVOKED BY MUSCULAR-CONTRACTION - CONTRIBUTIONS BY NEURAXIS LEVELS
PRESSOR REFLEX EVOKED BY MUSCULAR-CONTRACTION - CONTRIBUTIONS BY NEURAXIS LEVELS
复制标题
DOI：
10.1152/jappl.1985.59.2.459
复制
发表时间：
1985-01-01
影响因子：
3.3
通讯作者：
MITCHELL, JH
中科院分区：
文献类型：
--
作者：
IWAMOTO, GA;WALDROP, TG;MITCHELL, JH
肌肉收缩引起的压力反射（运动压力反射）是静态运动中心血管调节的一个重要模型。介导这种反射的中枢神经系统结构在很大程度上仍然是模糊的。神经轴的贡献选定水平在介导压力反射引起的肌肉收缩刺激腹根被检查。失智猫表现出比完整猫更大的压力反射。氯氯糖麻醉的猫，低刺激频率（5赫兹或反复抽搐）比高刺激频率（50赫兹或强直）的差异更明显。虽然在完整的麻醉猫中观察到对5赫兹刺激的抑制反应，但这似乎主要是由于麻醉水平，因为在非麻醉动物中没有观察到抑制反应。小脑切除术对失智动物的反射没有影响。进一步横断神经轴（尾侧至中丘水平）可减弱运动加压反射。脊髓猫表现出轻微的运动压力反射活动。这些结果阐明了加压反射在中枢神经系统中的表现，并在神经轴整合的几个层次上建立了反射的特征。
The pressor reflex evoked by muscular contraction (exercise pressor reflex) is one important model of cardiovascular adjustments during static exercise. The CNS structures mediating this reflex have remained largely obscure. The contribution of selected levels of the neuraxis in mediating the pressor reflex evoked by muscular contraction from stimulation of ventral roots was examined. Decerebrate cats exhibited larger pressor reflexes than those found in intact .alpha.-chloralose-anesthetized cats, a difference more apparent at low (5 Hz or repeated twitch) rather than at high (50 Hz or tetanic) stimulus frequencies. Although a depressor response to 5-Hz stimulation was observed in the intact anesthetized cats, it appeared to be primarily due to anesthetic level, since a depressor response was not observed in decerebrate animals (nonanesthetized). Cerebellectomy produced no changes in the reflexes of the decerebrate animal. Further transection of the neuraxis (caudal to the midcollicular level) attenuated the exercise pressor reflex. The spinal cat demonstrated slight evidence of exercise pressor reflex activity. These results provide clarification as to representation of this pressor reflex within the CNS and establish the reflex''s characteristics at several levels of neuraxis integration.