Association of serum bicarbonate levels with mortality in patients with non-dialysis-dependent CKD
Association of serum bicarbonate levels with mortality in patients with non-dialysis-dependent CKD
复制标题
DOI：
10.1093/ndt/gfn633
复制
发表时间：
2009-04-01
影响因子：
6.1
通讯作者：
Kalantar-Zadeh, Kamyar
中科院分区：
文献类型：
--
作者：
Kovesdy, Csaba P.;Anderson, John E.;Kalantar-Zadeh, Kamyar
背景代谢性酸中毒，通常表现为低血清碳酸氢盐水平，在慢性肾病（CKD）中很常见，似乎与透析患者的死亡率较高有关。目前尚不清楚在非透析依赖性CKD（NDD-CKD）患者中是否存在类似的相关性。我们使用多变量校正的考克斯模型来研究基线和时间变量血清碳酸氢盐（测量为总CO2）与1240例中度和晚期NDD-CKD男性患者的全因死亡率和透析前死亡率或终末期肾病复合终点结局之间的相关性。血清碳酸氢盐与全因死亡率呈显著的U型相关，基线血清碳酸氢盐水平的患者死亡率最高
Background. Metabolic acidosis, usually manifested by low serum bicarbonate level, is common in chronic kidney disease (CKD) and appears to be associated with higher mortality in dialysis patients. It is not known whether a similar association is present in patients with non-dialysis-dependent CKD (NDD-CKD).Methods. We used multivariable-adjusted Cox models to examine the association between baseline and time-variable serum bicarbonate (measured as total CO2) with the outcomes of all-cause mortality and the composite of pre-dialysis mortality or end-stage renal disease in 1240 male patients with moderate and advanced NDD-CKD.Results. Serum bicarbonate showed a significant U-shaped association with all-cause mortality, with the highest mortality rate observed in patients with baseline serum bicarbonate levels