Biologics and postbiologics: novel immunotherapeutics for the induction and maintenance of remission.
Biologics and postbiologics: novel immunotherapeutics for the induction and maintenance of remission.
复制标题
生物制剂和后生物制剂：用于诱导和维持缓解的新型免疫疗法。
DOI：
10.1016/j.drudis.2008.12.010
复制
发表时间：
2010
影响因子：
7.4
通讯作者：
Albani,Salvatore
中科院分区：
文献类型：
--
作者：
vanEden,Willem;Lisse,Jeffrey;Prakken,Berent;Albani,Salvatore
新工具的快速发展和分子免疫学的进步导致了一类称为生物制剂的药物。虽然有效，但这些疗法是昂贵的，通常需要连续施用，并且通常具有严重的副作用。本文综述了目前的治疗方法和对新一类治疗方法的需求。一类能够诱导和维持耐受性的新型药物将被认为是一种适合患者亚群的联合治疗可能带来更低成本和更有效的治疗。
Rapid growth in the development of new tools and advances in molecular immunology has led to a class of drugs called biologics. While effective, these therapies are costly, typically require continuous administration and often have serious side effects. This review focuses on current therapies and the need for a new class of therapies. A novel class of drugs able to induce and maintain tolerance will be paralleled with the notion that combination therapy appropriately tailored to patient subpopulations may hold the promise of less costly and more effective therapy.