Association between ischemia-modified albumin, lipids and inflammation biomarkers in patients with hypercholesterolemia
Association between ischemia-modified albumin, lipids and inflammation biomarkers in patients with hypercholesterolemia
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DOI：
10.1016/j.clinbiochem.2009.01.010
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发表时间：
2009-05-01
影响因子：
2.8
通讯作者：
Schetinger, Maria R. C.
中科院分区：
文献类型：
--
作者：
Duarte, Marta M. M. F.;Rocha, Joao B. T.;Schetinger, Maria R. C.
目的：本研究的目的是评估高胆固醇血症患者缺血修饰白蛋白（IMA）、脂质和炎症生物标志物之间的相关性，以及IMA可能参与动脉粥样硬化斑块发展和氧化应激。设计和方法：葡萄糖、总胆固醇、HDL胆固醇、LDL胆固醇、甘油三酯、氧化LDL（ox-LDL）、ox-LDL自身抗体、高敏C反应蛋白（hs-CRP），结果：高胆固醇血症组总胆固醇、LDL胆固醇、甘油三酯、ox-LDL、ox-LDL自身抗体、hs-CRP、IMA均高于对照组，HDL胆固醇低于对照组。我们观察到IMA与总胆固醇、LDL胆固醇、ox-LDL抗体和hs-CRP水平之间存在显著相关性。高敏C反应蛋白和总胆固醇，高密度脂蛋白胆固醇，低密度脂蛋白胆固醇，氧化-低密度脂蛋白，氧化-低密度脂蛋白自身抗体，和triglycerides.Conclusions：高胆固醇血症与炎症和氧化应激生物标志物的增加，它也降低了白蛋白的能力，结合钴由于缺血，导致IMA增加。IMA的形成似乎与氧化应激和动脉粥样硬化斑块的发展有关。(C)2009年加拿大临床化学家协会。爱思唯尔公司出版All rights reserved.
Objectives: The aim of this study was to evaluate the association between ischemia-modified albumin (IMA), lipids and inflammation biomarkers in patients with hypercholesterolemia, and the possible involvement of IMA in atheromatous plaque development and oxidative stress.Design and methods: Glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, oxidized LDL (ox-LDL), ox-LDL autoantibodies, high-sensitivity C reactive protein (hs-CRP), and IMA were measured in 37 subjects with hypercholesterolemia and 37 controls.Results: Total cholesterol, LDL cholesterol, triglycerides, ox-LDL, ox-LDL autoantibodies, hs-CRP, and IMA were higher in the hypercholesterolemia group, and HDL cholesterol levels were lower in this group. We observed significant correlations between IMA and total cholesterol, LDL cholesterol, ox-LDL antibodies, and hs-CRP levels. Significant correlations were also observed between hs-CRP and total cholesterol, HDL cholesterol, LDL cholesterol, ox-LDL, ox-LDL autoantibodies, and triglycerides.Conclusions: Hypercholesterolemia is associated with an increase in inflammatory and oxidative stress biomarkers, and it also reduces the capacity of albumin to bind cobalt owing to ischemia, resulting in an increased IMA. IMA formation appears to be associated with oxidative stress and atheromatous plaque development. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.