Suppression of Implanted MDA-MB 231 Human Breast Cancer Growth in Nude Mice by Dietary Walnut
Suppression of Implanted MDA-MB 231 Human Breast Cancer Growth in Nude Mice by Dietary Walnut
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DOI：
10.1080/01635580802065302
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发表时间：
2008-09-01
影响因子：
2.9
通讯作者：
Ion, Gabriela
中科院分区：
文献类型：
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作者：
Hardman, W. Elaine;Ion, Gabriela
核桃含有的成分可能会减缓癌症的生长，包括欧米伽3脂肪酸，植物甾醇，多酚，类胡萝卜素和褪黑激素。进行了一项初步研究，以确定食用核桃是否会影响植入裸鼠体内的MDA-MB 231人乳腺癌的生长。将肿瘤细胞注射到裸鼠中，所述裸鼠食用稍微修改为含有10%玉米油的AIN-76 A饮食。在肿瘤直径达到3至5毫米后，一组小鼠的饮食改变为包括磨碎的核桃，相当于人类每天56克（2盎司）。从第10天肿瘤大小开始分化，直到食用核桃的那组研究结束，（2.9 +/- 1.1 mm（3）/天;平均值+/-平均值的标准误差）显著小于（P < 0.05，生长率的t检验）比不食用核桃的组（14.6 +/- 1.3 mm（3）/天）。食用核桃的组的肝脏的二十碳五烯酸和二十二碳六烯酸分数显著高于不食用核桃的组。肿瘤细胞增殖减少，但凋亡没有改变，由于核桃消费。进一步的工作是值得的，以研究在人类癌症中的应用。
Walnuts contain components that may slow cancer growth including omega 3 fatty acids, phytosterols, polyphenols, carotenoids, and melatonin. A pilot study was performed to determine whether consumption of walnuts could affect growth of MDA-MB 231 human breast cancers implanted into nude mice. Tumor cells were injected into nude mice that were consuming an AIN-76A diet slightly modified to contain 10% corn oil. After the tumors reached 3 to 5 mm diameter, the diet of one group of mice was changed to include ground walnuts, equivalent to 56 g (2 oz) per day in humans. The tumor growth rate from Day 10, when tumor sizes began to diverge, until the end of the study of the group that consumed walnuts (2.9 +/- 1.1 mm(3)/day; mean +/- standard error of the mean) was significantly less (P < 0.05, t-test of the growth rates) than that of the group that did not consume walnuts (14.6 +/- 1.3 mm(3)/day). The eicosapentaenoic and docosahexaenoic acid fractions of the livers of the group that consumed walnuts were significantly higher than that of the group that did not consume walnuts. Tumor cell proliferation was decreased, but apoptosis was not altered due to walnut consumption. Further work is merited to investigate applications to cancer in humans.