HLA-DR4 genotype frequency and gender effect in familial rheumatoid arthritis.
HLA-DR4 genotype frequency and gender effect in familial rheumatoid arthritis.
复制标题
家族性类风湿关节炎中 HLA-DR4 基因型频率和性别效应。
DOI：
10.1111/j.1399-0039.1988.tb02092.x
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Khan,MK
中科院分区：
文献类型：
--
作者：
Khan,MA;Yamashita,TS;Reynolds,TL;Wolfe,F;Khan,MK
我们研究了75个无血缘关系的白人家庭的HLA - A、B、C和DR抗原，每个家庭都有多例成人发病的明确或典型性类风湿性关节炎（RA）（根据ARA标准）。男性和女性在RA的发病年龄和血清学特征上没有差异。女性（68%）和男性（71%）患者的HLA - DR4表型频率也无显著差异。观察到HLA - DR4基因型（纯合子、杂合子和缺乏HLA - DR4基因型）的频率在受影响和未受影响的个体之间差异显著（p<0.005）。然而，观察到的基因型分布与Hardy - Weinburg平衡的预期结果并无不同。携带DR4等位基因的数量（2个、1个或0个）与受影响的百分比之间存在直接相关（女性p<0.026，男性p<0.052）。这些发现强调了识别其他影响RA易感性的遗传决定因素的重要性，包括那些与性别相关的遗传决定因素。
We have studied HLA‐A, B, C, and DR antigens in 75 unrelated white families, each with multiple cases of adult‐onset definite or classical rheumatoid arthritis (RA) (by ARA criteria). There was no difference in age of onset or serological features of RA between males and females. HLA‐DR4 phenotype frequency among female (68%) and male (71%) patients also did not differ significantly. The observed frequencies of HLA‐DR4 genotypes (homozygous, heterozygous, and those lacking it) differed significantly (p<0.005) between affected and unaffected individuals. However, the observed genotype distribution did not differ from what is expected given the Hardy‐Weinburg equilibrium. There is a direct correlation between the number of DR4 allele(s) carried (two, one, or zero) and the percent affected (p<0.026 for females and p<0.052 for males). These findings highlight the importance of discerning the additional genetic determinants, including those that are gender‐associated, which influence susceptibility to RA.