Head and neck cancer associated with esophageal cancer.
Head and neck cancer associated with esophageal cancer.
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头颈癌与食道癌相关。
DOI：
10.1016/j.anl.2006.07.012
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
S. Sasaki
中科院分区：
文献类型：
--
作者：
A. Watanabe;M. Hosokawa;M. Taniguchi;H. Tsujie;S. Sasaki
背景多发性鳞状细胞癌(SCCs)常发生在呼吸道。本研究旨在探讨头颈部鳞状细胞癌(SCCHN)在食道癌中的发病率及临床特点。方法回顾1995年5月至2001年12月收治的1118例食道癌患者的临床资料。所有EC患者在治疗前、治疗后定期进行耳鼻咽喉科检查和咽喉镜检查。结果127例结直肠癌患者中有127例合并SCCHN(11.4%)。其中以SCCHN为指标者49例，EC为78例。115例发展为双重癌(SCCHN和EC)，9例发展为三重癌(2例SCCHN和EC)，3例发展为第4癌(3例SCCHN和EC)。49例SCCHN患者中，治疗后异时检测ECs 30例(A组)，同步检测ECs 20例(B组)。在78例指标性EC患者中，38例同步检测到SCCHN(C组)，54例异时检测到SCCHN(D组)。D组54例SCCHN分期分别为33、14、4、3(I-IV期)，明显早于A、B组的50例(P<0.001)。定期耳鼻咽喉科检查和咽镜筛查可早期发现原发EC患者的SCCHN。
BACKGROUNDMultiple squamous cell carcinomas (SCCs) frequently arise in the aerodigestive tract. This study aims to clarify the incidence of squamous cell carcinoma of the head and neck (SCCHN) in esophageal cancer (EC) and clinical features of SCCHN.METHODWe reviewed the records of 1118 EC patients treated from May 1995 to December 2001 in our institution. All patients with EC underwent otolaryngological examination and pharyngolaryngoscopy screening before and after its treatment periodically during their follow-up periods. The incidence, site and stage of SCCHNs were analyzed.RESULTA total of 127 patients had associated SCCHNs among all patients with EC (11.4%). Of these, the index antecedent tumor was SCCHN in 49 and EC in 78 patients. One hundred and fifteen patients developed double cancers (SCCHN and EC), 9 patients developed triple cancers (2 SCCHNs and EC) and 3 patients developed fourth cancers (3 SCCHNs and EC). Of 49 patients with the index SCCHN, 30 ECs were detected metachronously after its treatment (Group A) and 20 were synchronously (Group B). Of 78 patients with index EC, 38 SCCHNs were detected synchronously (Group C) and 54 SCCHNs were metachronously (Group D). The stages of 54 SCCHNs in the Group D were 33, 14, 4, 3 (Stages I–IV, respectively), which was significantly earlier than that of 50 SCCHNs in the Groups A and B (p<0.001).CONCLUSIONThe incidence of SCCHN in our EC patients was 11.4%. Periodic otolaryngological examination and pharyngoscopy screening can detect SCCHNs early in patients with primary EC.