Regulation of collagen type XVII expression by miR203a-3p in oral squamous cell carcinoma cells
Regulation of collagen type XVII expression by miR203a-3p in oral squamous cell carcinoma cells
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miR203a-3p对口腔鳞状细胞癌细胞中XVII型胶原蛋白表达的调节
DOI：
10.1093/jb/mvz024
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发表时间：
2019
期刊：
影响因子：
2.7
通讯作者：
Nakamura S.
中科院分区：
文献类型：
--
作者：
Yasukochi A;Kawakubo-Yasukochi T;Morioka M;Hazekawa M;Nishinakagawa T;Ono K;Nakashima M;Nakamura S.
XVII型胶原蛋白（COL 17）在各种组织中表达，其异常表达与肿瘤进展相关。在这项研究中，我们研究了COL 17表达的调控在口腔鳞状细胞癌（OSCC）使用细胞系NA，SAS，Ca 9 -22，和Sa 3。在SAS中，顺铂激活p53后诱导COL 17;然而，这种作用在NA中更有限，在具有突变的p53的Ca 9 -22和Sa 3中几乎没有。此外，发现在所有细胞系中，COL 17受miR 203 a-3 p调节。我们的数据表明，在口腔鳞癌细胞系中，COL 17的表达受到p53和miR 203 a-3 p的调控。
Collagen type XVII (COL17) is expressed in various tissues and its aberrant expression is associated with tumour progression. In this study, we investigated the regulation of COL17 expression in oral squamous cell carcinoma (OSCC) using the cell lines NA, SAS, Ca9-22, and Sa3. COL17 was induced upon p53 activation by cisplatin in SAS; however, this effect was more limited in NA and hardly in Ca9-22 and Sa3, with mutated p53. Moreover, COL17 was found to be regulated by miR203a-3p in all cell lines. Our data suggest that COL17 expression in OSCC cell lines is regulated by p53 and miR203a-3p.