SERUM ALPHA-FETOPROTEIN - DIAGNOSTIC SIGNIFICANCE IN LIVER-DISEASE
SERUM ALPHA-FETOPROTEIN - DIAGNOSTIC SIGNIFICANCE IN LIVER-DISEASE
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DOI：
10.1136/bmj.2.5918.527
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发表时间：
1974-01-01
影响因子：
105.7
通讯作者：
SEPPALA, M
中科院分区：
文献类型：
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作者：
RUOSLAHTI, E;SALASPURO, M;SEPPALA, M
24例原发性肝癌患者中19例（79%）血清甲胎蛋白升高，311例其他肝病患者中32例（10%）血清甲胎蛋白升高。在肝炎病例中升高是短暂的，在两名肝硬化患者停止饮酒后也观察到短暂的升高。甲胎蛋白水平超过500 ng/ml在原发性肝癌中比在其他肝脏疾病中常见30-50倍。水平的升高似乎反映了原发性癌症以外的肝脏疾病的肝再生程度。
Raised serum α-fetoprotein levels measured by radioimmunoassay were found in 19 out of 24 (79%) patients with primary liver cancer and in 32 out of 311 (10%) patients with other liver diseases. The rise was transient in cases of hepatitis and a transient rise was also seen after alcohol intake ceased in two patients with cirrhosis. α-Fetoprotein levels exceeding 500 ng/ml were 30-50 times more common in primary liver cancer than in other liver diseases. A rise in level seems to reflect the extent of liver regeneration in liver diseases other than primary cancer.