Dietary intake of aflatoxins in the adult Malaysian population - an assessment of risk
Dietary intake of aflatoxins in the adult Malaysian population - an assessment of risk
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DOI：
10.1080/19393210.2012.713028
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发表时间：
2012-01-01
影响因子：
2.9
通讯作者：
Sugita-Konishi, Y.
中科院分区：
文献类型：
--
作者：
Chin, C. K.;Abdullah, A.;Sugita-Konishi, Y.
通过分析236种“即食”食品中的黄曲霉毒素，估计了马来西亚成人饮食中的黄曲霉毒素暴露量。黄曲霉毒素B1（AFB 1）的膳食暴露量范围为24.3至34.00 ng/kg体重/天（下限到上限），花生是主要贡献者。这种暴露的估计肝癌风险为0.61-0.85癌症/10万人口/年，占肝癌病例的12.4%-17.3%。排除高于15微克/千克的黄曲霉毒素B1发生率数据，暴露量减少65%-91%，为2.27-11.99纳克/千克b.w./每天，将癌症风险降低到0.06-0.30癌症/100，000人口/年（贡献1.2%-6.1%肝癌病例）。进一步将黄曲霉毒素B_1的最大限量从15 μ g/kg降低到5 μ g/kg，暴露量下降3%-7%，达到0.47-10.26 ng/kg b.w./每日摄入AFB 1的风险估计为0.01-0.26例癌症/10万人/年（0.2%-5.1%的肝癌病例归因于膳食AFB 1）。这些结果表明，目前的最高限额足以保护马来西亚人的健康。
Exposure to aflatoxins in the adult Malaysian diet was estimated by analysing aflatoxins in 236 food composites prepared as "ready for consumption". Dietary exposure to aflatoxin B1 (AFB1) ranged from 24.3 to 34.00 ng/kg b.w./day (lower to upper bound), with peanuts being the main contributor. Estimated liver cancer risk from this exposure was 0.61-0.85 cancers/100,000 population/year, contributing 12.4%-17.3% of the liver cancer cases. Excluding AFB1 occurrence data higher than 15 mu g/kg reduced exposure by 65%-91% to 2.27-11.99 ng/kg b.w./day, reducing the cancer risk to 0.06-0.30 cancers/100,000 population/year (contributing 1.2%-6.1% liver cancer cases). Reducing further the ML of AFB1 from 15 to 5 mu g/kg yielded 3%-7% greater drop in the exposure to 0.47-10.26 ng/kg b.w./day with an estimated risk of 0.01-0.26 cancers/100,000 population/year (0.2%-5.1% liver cancer cases attributed to dietary AFB1). These findings indicate that current MLs are adequate in protecting Malaysians' health.