Toxicity of coplanar polychlorinated biphenyls in avian embryos
Toxicity of coplanar polychlorinated biphenyls in avian embryos
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共面多氯联苯对禽类胚胎的毒性
DOI：
10.1016/0045-6535(89)90405-0
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发表时间：
1989
期刊：
影响因子：
8.8
通讯作者：
B. Brunström
中科院分区：
文献类型：
--
作者：
B. Brunström
测定了多种多氯联苯（PCBs）对禽类胚胎的毒性。在鸡胚胎中，非邻氯取代的共面多氯联苯被证明是非常有毒的（胚胎死亡和畸形）。3,3 ', 4,4 '， 5-五氯联苯（PeCB）是鸡胚7-乙氧基间苯二酚o -去乙基酶（EROD）的最有效诱导剂。3,3 ', 4,4 ' -四氯联苯（TeCB）的毒性仅比五氯联苯小几倍，而TeCB在一个邻位氯化的类似物的毒性比五氯联苯小3 - 4个数量级。其他8种鸟类胚胎对TeCB的敏感性明显低于鸡胚胎。除了四氯联苯外，共面五氯联苯在火鸡胚胎中的毒性小于鸡胚胎，这表明对TeCB敏感性的种间差异也适用于其他Ah受体配体。
The toxicities of various polychlorinated biphenyls (PCBs) were measured in avian embryos. In chick embryos the non-ortho chlorine substituted coplanar PCBs proved to be very toxic (embryolethality and malformations). 3, 3′, 4, 4′, 5-Pentachlorobiphenyl (PeCB) had the highest embryotoxicity of the tested chlorobiphenyls and was the most potent inducer of 7-ethoxyresorufin O-deethylase (EROD) in chick embryos. Whereas 3, 3′, 4, 4′-tetrachlorobiphenyl (TeCB) was only a few times less toxic than the pentachlorobiphenyl, the analogs of TeCB chlorinated at one ortho-position were 3–4 orders of magnitude less toxic than PeCB. Embryos of eight other avian species were considerably less sensitive than chick embryos to TeCB. In addition to this tetrachlorobiphenyl the coplanar pentachlorobiphenyl was less toxic in turkey embryos than in chick embryos, indicating that the interspecific differences in sensitivity to TeCB also are valid for other Ah receptor ligands.