Conditioned place aversion induced by intragastric administration of ethanol in rats
Conditioned place aversion induced by intragastric administration of ethanol in rats
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DOI：
10.1016/j.pbb.2004.01.010
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发表时间：
2004-04-01
影响因子：
3.6
通讯作者：
Cunningham, CL
中科院分区：
文献类型：
--
作者：
Fidler, TL;Bakner, L;Cunningham, CL
大多数研究乙醇诱导的大鼠位置条件化的实验都产生了条件性位置厌恶（CPA）。乙醇诱导的大鼠条件性位置偏爱（CPP）的少数报告之一，选择性繁殖的酒精偏好（msP）大鼠显示CPP在一个偏见的程序时，乙醇通过胃内（IG）导管给药，但不是当乙醇通过腹腔注射或灌胃给药。这一发现表明，重要的管理和遗传变量的结果的位置条件反射研究的途径。我们进行了三个实验，检查IG乙醇诱导的遗传异质性大鼠的位置条件反射，以测试早期发现的一般性。我们采用了一个公正的程序，是更敏感的检测偏好的变化，在任何方向（偏好或厌恶）。未接触乙醇的大鼠（实验1）和经历过乙醇的Sprague-Dawley大鼠（实验2）显示出稳健的CPA。在实验3中，改变输注速率，以观察实验1和2中观察到的CPA是否是从清醒状态快速过渡到中毒状态的结果。两组都表现出较强的CPA。总体而言，目前的研究结果是一致的CPA在异质性大鼠先前的研究结果，这表明乙醇产生CPA的令人厌恶的吸收后效应。(C)2004年爱思唯尔公司All rights reserved.
Most experiments investigating ethanol-induced place conditioning in rats have produced conditioned place aversion (CPA). In one of the few reports of ethanol-induced conditioned place preference (CPP) in rats, selectively bred alcohol-preferring (msP) rats showed CPP in a biased procedure when ethanol was administered via intragastric (IG) catheter but not when ethanol was administered via intraperitoneal injection or by gavage. This finding suggests the importance of both route of administration and genetic variables to the outcome of place conditioning studies. We conducted three experiments examining place conditioning induced by IG ethanol in genetically heterogeneous rats to test the generality of the earlier finding. We employed an unbiased procedure that is more sensitive to detecting preference changes in either direction (preference or aversion). Ethanol-naive (Experiment 1) and ethanol-experienced Sprague-Dawley rats (Experiment 2) showed robust CPA. In Experiment 3, infusion rate was varied to see if the CPA observed in Experiments 1 and 2 was a result of the rapidity of the transition from the sober to the intoxicated states. Both groups showed strong CPA. Overall, the present findings are consistent with previous findings of CPA in heterogeneous rats, suggesting that the aversive postabsorptive effects of ethanol produce CPA. (C) 2004 Elsevier Inc. All rights reserved.