Modulation of Vasomotor Function by Perivascular Adipose Tissue of Renal Artery Depends on Severity of Arterial Dysfunction to Nitric Oxide and Severity of Metabolic Parameters.
Modulation of Vasomotor Function by Perivascular Adipose Tissue of Renal Artery Depends on Severity of Arterial Dysfunction to Nitric Oxide and Severity of Metabolic Parameters.
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DOI：
10.3390/biom12070870
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发表时间：
2022-06-23
期刊：
影响因子：
5.5
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中科院分区：
文献类型：
--
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血管周围脂肪组织（PVAT）增强SHRSP.Z-Leprfa/IzmDmcr大鼠（SPZF）（一种代谢综合征模型）肠系膜动脉的血管舒张。本研究观察并比较了PVAT对SPZF和SHR/NDmcr-cp大鼠（CP）肾动脉的影响。从23周龄的SPZF和CP中分离出有和没有PVAT的肾动脉。PVAT对乙酰胆碱和硝普钠诱导的舒张作用的影响进行了研究，使用苯肾上腺素收缩动脉环的生物测定。乙酰胆碱诱导的松弛无PVAT在SPZF和CP分别为0.7和0.5倍，女性比男性低。在PVAT的存在下，乙酰胆碱诱导的舒张增加1.4和2倍，男性和女性CP，分别，但没有不同的SPZF。硝普钠诱导的松弛与无PVAT是0.7倍，女性比男性的SPZF，但没有不同的CP。血管紧张素II 1型受体（AT 1 R）/AT 1 R相关蛋白mRNA比值在CP中低于SPZF，与有无PVAT的动脉舒张差异呈负相关。SPZF组和CP组对肾动脉PVAT的影响不同。SPZF PVAT中较高水平的增强AT 1 R活性可能通过损害血管平滑肌对一氧化氮的反应来驱动这些差异。
Perivascular adipose tissue (PVAT) enhances vascular relaxation of mesenteric arteries in SHRSP.Z-Leprfa/IzmDmcr rats (SPZF), a metabolic syndrome model. We investigated and compared the effects of PVAT on the renal artery in SPZF with those on SHR/NDmcr-cp rats (CP). Renal arteries with and without PVAT were isolated from 23-week-old SPZF and CP. The effects of PVAT on acetylcholine- and nitroprusside-induced relaxation were examined using bioassays with phenylephrine-contracted arterial rings. Acetylcholine-induced relaxations without PVAT in SPZF and CP were 0.7- and 0.5-times lower in females than in males, respectively. In the presence of PVAT, acetylcholine-induced relaxations increased 1.4- and 2-times in male and female CP, respectively, but did not differ in SPZF. Nitroprusside-induced relaxation with and without PVAT was 0.7-times lower in female than in male SPZF but did not differ in CP. Angiotensin-II type-1 receptor (AT1R)/AT1R-associated protein mRNA ratios were lower in CP than in the SPZF and negatively correlated with the difference in arterial relaxation with and without PVAT. The effects of renal artery PVAT differed between the SPZF and CP groups. Higher levels of enhanced AT1R activity in SPZF PVAT may drive these differences by impairing the vascular smooth muscle responses to nitric oxide.
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影响因子：
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