Reduction of common motoneuronal drive on the affected side during walking in hemiplegic stroke patients
Reduction of common motoneuronal drive on the affected side during walking in hemiplegic stroke patients
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DOI：
10.1016/j.clinph.2008.07.283
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发表时间：
2008-12-01
影响因子：
4.7
通讯作者：
Conway, B. A.
中科院分区：
文献类型：
--
作者：
Nielsen, J. B.;Brittain, J. -S.;Conway, B. A.
目的：本研究的目的是使用运动单元耦合在时域和频域中获得证据的运动神经元驱动的变化，在行走在Subjectswithstroke.Methods：成对的胫骨前肌（TA）肌电图活动进行了采样，在摆动阶段的跑步机行走在8名受试者单侧stroke.Results：在未受影响的一侧。从累积量密度中窄的中心峰值的存在以及从在10-25 Hz频带中这些信号之间的显著相干性的存在，短期同步是明显的。这种短期同步性的指标要么不存在，要么在受影响的一侧非常小。相反，观察到明显的10 Hz耦合。结论：这表明，减少皮质脊髓驱动脊髓运动神经元是负责减少短期同步性和连贯性在10-25 Hz频段的偏瘫患者在行走中患侧。意义：这对于了解步态能力下降的机制和制定步态恢复的新策略具有重要意义。(c)2008年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: The objective of this study was to Use motor Unit Coupling in the time and frequency domains to obtain evidence of changes in motoneuronal drive during walking in Subjects with stroke.Methods: Paired tibialis anterior (TA) EMG activity was sampled during the swing phase of treadmill walking in eight subjects with unilateral stroke.Results: On the unaffected side. short-term synchronization was evident from the presence of a narrow central peak in cumulant densities and from the presence of significant coherence between these signals in the 10-25 Hz band. Such indicators of short-term synchrony were either absent or very small on the affected side. instead, pronounced 10 Hz coupling was observed.Conclusions: It is suggested that reduced corticospinal drive to the spinal motoneurones is responsible for the reduced short-term synchrony and coherence in the 10-25 Hz frequency band on the affected side in hemiplegic patients during walking.Significance: This is of importance for understanding the mechanisms responsible for reduced gait ability and development of new strategies for gait restoration. (c) 2008 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.