Detection of Lesions in Mesial Temporal Lobe Epilepsy by Using MR Fingerprinting
Detection of Lesions in Mesial Temporal Lobe Epilepsy by Using MR Fingerprinting
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使用 MR 指纹识别内侧颞叶癫痫病灶
DOI：
10.1148/radiol.2018172131
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发表时间：
2018-09-01
期刊：
影响因子：
19.7
通讯作者：
Zhong, Jianhui
中科院分区：
文献类型：
--
作者：
Liao, Congyu;Wang, Kang;Zhong, Jianhui
目的：应用MR指纹技术提高内侧颞叶癫痫(MTLE)患者海马硬化(HS)的诊断率，并与T1和T2加权MR图像的视觉评估进行比较。材料和方法：在2016年4月至11月期间进行的前瞻性研究中，对连续的耐药MTLE患者进行了T1和T2图，并进行了组织分割。对33例MTLE患者(23名女性和10名男性；平均年龄32.6岁；年龄范围16-60岁)和30名健康受试者(20名女性和10名男性；平均年龄28.8岁；年龄范围18-40岁)的T1和T2图进行了比较。结果：33例MTLE患者中，32例(96.9%)的诊断符合率(即2.5min的MR指纹检查对HS的诊断率为96.9%；95%可信区间：84.9%，100%)，较常规MR检查诊断准确率提高(P=1.92×10(-12))，诊断准确率为69.7%，95%可信区间：51.5%，81.6%。33例MTLE患者和健康对照组的萎缩和正常海马区比较发现，海马区病变的T1和T2值均高于正常海马区(T1：1361毫秒+/-85比1249毫秒+/-59；T2：135毫秒+/-15比104毫秒+/-9；P
Purpose: To improve diagnosis of hippocampal sclerosis (HS) in patients with mesial temporal lobe epilepsy (MTLE) by using MR fingerprinting and compare with visual assessment of T1- and T2-weighted MR images.Materials and Methods: For this prospective study performed between April and November 2016, T1 and T2 maps were obtained and tissue segmentation performed in consecutive patients with drug-resistant MTLE with unilateral or bilateral HS. T1 and T2 maps were compared between 33 patients with MTLE (23 women and 10 men; mean age, 32.6 years; age range, 16-60 years) and 30 healthy participants (20 women and 10 men; mean age, 28.8 years; age range, 18-40 years). Differences in individual bilateral hippocampi were compared by using a Wilcoxon signed rank test, whereas the Wilcoxon rank-sum test was used for difference analysis between healthy control participants and patients with MTLE.Results: The diagnosis rate (ie, ratio of HS diagnosed on the basis of a 2.5-minute MR fingerprinting examination compared with standard methods: MRI, electroencephalography, and PET) was 32 of 33 (96.9%; 95% confidence interval: 84.9%, 100%), reflecting improved accuracy of diagnosis (P = 1.92 x 10(-12)) over routine MR examinations that had a diagnostic rate of 23 of 33 (69.7%; 95% confidence interval: 51.5%, 81.6%). The comparison between atrophic and normal-appearing hippocampus in 33 patients with MTLE and healthy control participants demonstrated that both T1 and T2 values in HS lesions were higher than those of normal hippocampal tissue of healthy participants (T1: 1361 msec +/- 85 vs 1249 msec +/- 59, respectively; T2: 135 msec +/- 15 vs 104 msec +/- 9, respectively; P