Effect of Antiarrhythmic Drugs on the Cycle Length-Dependent Action Potential Duration in Dog Purkinje and Ventricular Muscle Fibers
Effect of Antiarrhythmic Drugs on the Cycle Length-Dependent Action Potential Duration in Dog Purkinje and Ventricular Muscle Fibers
复制标题
抗心律失常药物对狗浦肯野肌纤维和心室肌纤维周期长度依赖性动作电位持续时间的影响
DOI：
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发表时间：
1986
影响因子：
3
通讯作者：
B. Surawicz
中科院分区：
文献类型：
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作者：
A. Varró;Y. Nakaya;V. Elharrar;B. Surawicz
总结：我们在存在以下物质的情况下，检查了心脏犬浦肯野（P）和心室（V）肌纤维在宽周期长度（CL）范围内的稳态动作电位时程（APD）：利多卡因（L）4和8 μg/ml，美西律（M）4和8 μg/ml，氟卡尼（F）1和4 μg/ml，丙吡胺（D）3.1和10 μg/ml，奎尼丁（Q）2.5，5，甲苯磺酸溴苄铵（B）5和10 μ g/ml;索他洛尔（S）5 μg/ml。除B和S外，所有药物均缩短P纤维平台时间，增加2相复极斜率，降低3相复极斜率，缩短（L，M，Q，F）或延长（D）APD。B、S延长动作电位时程，对复极2、3相斜率无明显影响。每种药物改变APD和CL之间的关系，根据以下三种模式之一：（a）L，M，Q和F缩短APD长CL比短CL更多;（B）D延长APD短CL比长CL更多;（c）B和S延长APD长CL比短CL更多。在V纤维中，F、Q和B使APD延长，L和M使APD缩短。药物引起的APD与CL关系的变化与P纤维相同。结果表明，药物引起的APD和CL之间的关系的变化可以预测药物对复极过程的影响。
Summary: We examined the steady-state action potential duration (APD) within a wide range of cycle lengths (CL) in cardiac dog Purkinje (P) and ventricular (V) muscle fibers in the presence of: lidocaine (L) 4 and 8 μg/ml, mexiletine (M) 4 and 8 μg/ml, flecainide (F) 1 and 4 μg/ml, disopyramide (D) 3.1 and 10 μg/ml, quinidine (Q) 2.5, 5, and 10 μg/ml, bretylium tosylate (B) 5 and 10 μgl ml, and sotalol (S) 5 μg/ml. In the P fibers, all drugs except for B and S shortened plateau duration, increased slope of phase 2 and decreased slope of phase 3 repolarization, and either shortened (L, M, Q, F) or prolonged (D) APD. B and S lengthened APD and did not change significantly the slopes of phase 2 and 3 of repolarization. Each drug altered the relation between APD and CL according to one of the following three patterns: (a) L, M, Q, and F shortened APD more at long than at short CL; (b) D lengthened APD more at short than at long CL; (c) B and S lengthened APD more at long that at short CL. In the V fibers, APD was lengthened by F, Q, and B, and shortened by L and M. The drug-induced changes in the relation between APD and CL were as in the P fibers. The results suggest that the drug-induced changes in the relation between APD and CL can be predicted from the drug effects on the course of repolarization.