Novel Cost-Effective Microfluidic Chip Based on Hybrid Fabrication and Its Comprehensive Characterization
Novel Cost-Effective Microfluidic Chip Based on Hybrid Fabrication and Its Comprehensive Characterization
复制标题
DOI：
10.3390/s19071719
复制
发表时间：
2019-04-01
期刊：
影响因子：
3.9
通讯作者：
Radonic, Vasa
中科院分区：
文献类型：
--
作者：
Kojic, Sanja P.;Stojanovic, Goran M.;Radonic, Vasa
微流控技术是现代科学技术中最具吸引力和发展最快的领域之一，在医学、生物学和化学领域都有广泛的应用。为了解决微流控器件的先进设计挑战，研究重点是开发高效、低成本、快速、广泛应用的制造技术。本文首次提出了采用混合制造技术制造微流控芯片的方法，即将PVC（聚氯乙烯）箔和LTCC（低温共烧陶瓷）陶瓷带组合在一起，采用具有成本效益的成像技术和激光微加工工艺。测定了制备的微流控芯片的光学和介电性能。在非烘烤条件下，对作为中间层的陶瓷带进行了力学表征，并测定了杨氏模量和硬度。研究结果证实了该技术在快速制造低成本、高可靠性和可重复性的微流控芯片方面具有良好的潜力。所进行的微流控测试表明，所述微流控芯片可以抵抗比使用标准成像技术制造的芯片高3000倍的流速。
Microfluidics, one of the most attractive and fastest developed areas of modern science and technology, has found a number of applications in medicine, biology and chemistry. To address advanced designing challenges of the microfluidic devices, the research is mainly focused on development of efficient, low-cost and rapid fabrication technology with the wide range of applications. For the first time, this paper presents fabrication of microfluidic chips using hybrid fabrication technologya grouping of the PVC (polyvinyl chloride) foils and the LTCC (Low Temperature Co-fired Ceramics) Ceram Tape using a combination of a cost-effective xurography technique and a laser micromachining process. Optical and dielectric properties were determined for the fabricated microfluidic chips. A mechanical characterization of the Ceram Tape, as a middle layer in its non-baked condition, has been performed and Young's modulus and hardness were determined. The obtained results confirm a good potential of the proposed technology for rapid fabrication of low-cost microfluidic chips with high reliability and reproducibility. The conducted microfluidic tests demonstrated that presented microfluidic chips can resist 3000 times higher flow rates than the chips manufactured using standard xurography technique.