Pleiotropy and life history evolution in Drosophila melanogaster: uncoupling life span and early fecundity.
Pleiotropy and life history evolution in Drosophila melanogaster: uncoupling life span and early fecundity.
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DOI：
10.1093/gerona/gls226
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发表时间：
2013-05
期刊：
影响因子：
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通讯作者：
A. Khazaeli;J. Curtsinger
中科院分区：
文献类型：
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作者：
A. Khazaeli;J. Curtsinger
人工选择繁殖年龄较晚的黑腹果蝇种群会进化出更长的寿命，在某些情况下，还会降低早期的繁殖力。这种负相关性被广泛解释为拮抗多效性的证据。在这里，我们展示了在重组基因组中这种相关性被打破。一个能使成虫寿命延长20%的主要数量性状基因座对早期繁殖力没有明显影响。一些重组的基因类型是超级苍蝇，既表现出早期繁殖力的提高，又表现出长寿。早期繁殖力与寿命的遗传相关不为零，而中年繁殖力的遗传相关为正相关，且具有统计学意义，表明特定年龄适应。这一结果与负多效性的主导作用不一致，但可以用多效性和复合非多效性元素的混合来理解。寿命和早期繁殖力可能在基因上是分离的。
Populations of Drosophila melanogaster that have been artificially selected for late age of reproduction evolve longer life spans and, in some cases, reduced early fecundity. The negative correlation is widely interpreted as evidence of antagonistic pleiotropy. Here, we show that the correlation breaks down in recombinant genomes. A major quantitative trait locus that increases adult life span by 20% has no detectable effect on early fecundity. Several recombinant genotypes are superflies, exhibiting both elevated early fecundity and long life. The genetic correlation of early fecundity and life span is not different from zero, while the midlife fecundity correlation is positive and statistically significant, suggesting age-specific adaptation. The results are not consistent with a dominant role for negative pleiotropy, but can be understood in terms of a mixture of pleiotropic and recombining nonpleiotropic elements. Life span and early fecundity can be genetically uncoupled.