Osteoclast responses to lipopolysaccharide, parathyroid hormone and bisphosphonates in neonatal murine calvaria analyzed by laser scanning confocal microscopy
Osteoclast responses to lipopolysaccharide, parathyroid hormone and bisphosphonates in neonatal murine calvaria analyzed by laser scanning confocal microscopy
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DOI：
10.1369/jhc.5a6630.2005
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发表时间：
2005-12-01
影响因子：
3.2
通讯作者：
Shinoda, H
中科院分区：
文献类型：
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作者：
Suzuki, K;Takeyama, S;Shinoda, H
由于骨重塑中破骨细胞的发育和活性严重依赖于细胞-细胞和细胞-基质的相互作用，我们使用激光共聚焦显微镜研究了破骨细胞对培养的新生儿颅骨中脂多糖（LPS; 10 μ g/ml）、甲状旁腺激素（PTH; 10(-8) M）和双磷酸盐（bp； 1-25 μ M氯膦酸盐或0.1-2.5 μ M米塞膦酸盐）的反应。经LPS或PTH治疗后(
Because the development and activity of osteoclasts in bone remodeling is critically dependent on cell-cell and cell-matrix interactions, we used laser confocal microscopy to study the response of osteoclasts to lipopolysaccharide (LPS; 10 mu g/ml), parathyroid hormone (PTH; 10(-8) M), and bisphosphonates (BPs; 1-25 mu M clodronate or 0.1-2.5 mu M risedronate) in cultured neonatal calvaria. Following treatment with LPS or PTH (