Epithelial-Mesenchymal Plasticity in Tumor Immune Evasion.
Epithelial-Mesenchymal Plasticity in Tumor Immune Evasion.
复制标题
肿瘤免疫逃避中的上皮-间充质可塑性。
DOI：
10.1158/0008-5472.can-21-4370
复制
发表时间：
2022-07-05
期刊：
影响因子：
11.2
通讯作者：
中科院分区：
文献类型：
--
作者：
Epithelial-mesenchymal transition (EMT) is a fundamental process that occurs during embryogenesis and tissue repair. However, EMT can be hijacked by malignant cells, where it may promote immune evasion and metastasis. Classically considered a dichotomous transition, EMT in cancer has recently been considered a plastic process whereby malignant cells display and interconvert among hybrid epithelial/mesenchymal (E/M) states. Epithelial-mesenchymal plasticity (EMP) and associated hybrid E/M states are divergent from classical EMT with unique immunomodulatory effects. Here, we review recent insights into the EMP-immune crosstalk, highlighting possible mechanisms of immune evasion conferred by hybrid E/M states and roles of immune cells in EMP.
